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Vitamin D requirements and supplementation during pregnancy

Hollis, Bruce W.; Wagner, Carol L.

Current Opinion in Endocrinology & Diabetes and Obesity: December 2011 - Volume 18 - Issue 6 - p 371–375
doi: 10.1097/MED.0b013e32834b0040
Parathyroids, bone and mineral metabolism: Edited by Vin Tangpricha

Purpose of review The topic of vitamin D supplementation during pregnancy is very controversial. This review attempts to provide balanced knowledge with respect to this topic gained in the past 18 months.

Recent findings Two recent reports, one by the Institute of Medicine, and one by The Endocrine Society are greatly divergent with respect to the nutritional requirement for vitamin D, as well as, the level of circulating 25-hydroxyvitamin D that is desirable. These recommendations will be discussed along with recent observational data and a recently completed randomized controlled trial dealing with vitamin D requirements during pregnancy.

Summary Current evidence supports the concept that circulating 25-hydroxyvitamin D should be 40–60 ng/ml (100–150 nmol) during pregnancy and a daily intake of 4000 IU vitamin D3 is required to attain that circulating level.

Medical University of South Carolina, Charleston, South Carolina, USA

Correspondence to Bruce W. Hollis, PhD, Department of Pediatrics, Medical University of South Carolina, Darby Children's Research Institute, 173 Ashley Avenue, Room 313, Charleston, SC 29425, USATel: +1 843 792 6854; fax: +1 843 792 1844; e-mail:

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