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Sensor-augmented pump therapy in type 1 diabetes

Weinzimer, Stuart A; Tamborlane, William V

Current Opinion in Endocrinology, Diabetes and Obesity: April 2008 - Volume 15 - Issue 2 - p 118–122
doi: 10.1097/MED.0b013e3282f7960b
Diabetes and the endocrine pancreas: Edited by Allison B. Goldfine

Purpose of review Recent developments in technology have ushered in a new era of managing type 1 diabetes. Continuous glucose monitoring is rapidly becoming an accepted adjunct to traditional self-monitoring of plasma glucose, and the marriage of continuous glucose sensors to continuous subcutaneous insulin infusion is the first step towards the development of a true artificial pancreas. The purpose of this review is to familiarize the reader with the new glucose sensors and discuss the literature evaluating their accuracy and effectiveness.

Recent findings Current models of continuous glucose sensors are still less accurate than traditional methods of blood glucose monitoring but provide information regarding trends that cannot be obtained with blood testing. Short-term studies of continuous glucose sensors have demonstrated reduction in glycosylated hemoglobin levels and time spent in hypo- and hyperglycemic ranges. Patient acceptance and satisfaction with sensors has been shown to depend on the quality of the data, comfort of wear, and ease of use.

Summary Sensor-augmented pump therapy represents a landmark improvement in diabetes treatment and will likely become the standard of care. Future work should focus on improvements in sensor accuracy and development of user-friendly algorithms to assist patients with self-management.

Department of Pediatrics, Center for Clinical Investigation, Yale University School of Medicine, New Haven, Connecticut, USA

Correspondence to Stuart A. Weinzimer, MD, Yale University Department of Pediatrics, PO Box 208064, 333 Cedar Street, New Haven, CT 06520-8064, USA Tel: +1 203 785 7924; fax: +1 203 737 2829; e-mail: stuart.weinzimer@yale.edu

© 2008 Lippincott Williams & Wilkins, Inc.