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DAX-1 and the adrenal cortex

Lalli, Enzo MD; Sassone-Corsi, Paolo PhD

Current Opinion in Endocrinology & Diabetes: June 1999 - Volume 6 - Issue 3 - p 185
Adrenal Cortex
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DAX-1 is an unusual member of the nuclear hormone receptor superfamily. Its mutations cause adrenal hypoplasia congenita, a disease of the adrenal cortex that is characterized by an impairment of the genesis of the permanent zone. Here we present an overview of the pathologic and clinical features of adrenal hypoplasia congenita and describe some recent advances in the understanding of the biologic role of DAX-1.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS-INSERM-ULP, Strasbourg, France

Correspondence to Paolo Sassone-Corsi, PhD, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS-INSERM-ULP, B.P. 163, 67404 Illkirch, Strasbourg, France; e-mail: paolosc@igbmc.u-strasbg.fr

© 1999 Lippincott Williams & Wilkins, Inc.