REVIEW: PDF OnlyBone health in diabetes Indian perspectivePal, Rimesh; Bhadada, Sanjay KumarAuthor Information Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India Correspondence to Sanjay Kumar Bhadada, Professor and Head, Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. E-mail: [email protected] Current Opinion in Endocrinology & Diabetes and Obesity: May 11, 2021 - Volume Publish Ahead of Print - Issue - doi: 10.1097/MED.0000000000000640 Buy PAP Metrics Abstract Purpose of review Despite estimated 77 million people having diabetes, bone health in Asian Indians with diabetes is largely unknown. This review summarizes the published literature on fracture risk and factors affecting it in Asian Indians with diabetes. Recent findings Data on fracture prevalence in diabetes is limited; one study showed that diabetes was associated with a significantly higher number of fractures compared with subjects without diabetes (4% vs. 2.4%, P < 0.05). The prevalence of osteoporosis in Asian Indians with type 2 diabetes mellitus (T2D) varies from 35.5 to 49.5%. Studies have shown an increased, similar or lower areal bone mineral density (BMD) at the lumbar spine and/or hip in patients with T2D compared to controls without diabetes. On the contrary, the BMD in patients with type 1 diabetes mellitus (T1D) is modestly low compared to age- and sex-matched healthy controls without diabetes. Recent studies have shown compromised mechanical, material and compositional properties of trabecular bone in Asian Indians with T2D suggesting deteriorated bone quality as one of the contributors of high fracture risk. Summary Further research is needed to generate evidence-based guidelines to prevent and manage bone fragility in Asian Indians with diabetes. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.