LIPIDS: Edited by Gerald F. WattsPolygenic risk scores for the diagnosis and management of dyslipidemiaBrunham, Liam R.a,b,c; Trinder, Marka Author Information aCentre for Heart Lung Innovation bDepartment of Medicine cDepartment of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada Correspondence to Dr Liam R. Brunham, Centre for Heart Lung Innovation, Room 166-1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada. Tel: +1 604 682 2344 x63929; fax: +1 604 806 9274; e-mail: [email protected] Current Opinion in Endocrinology & Diabetes and Obesity: April 2022 - Volume 29 - Issue 2 - p 95-100 doi: 10.1097/MED.0000000000000708 Buy Metrics Abstract Purpose of review To review current progress in the use of polygenic risk scores for lipid traits and their use in the diagnosis and treatment of lipid disorders. Recent findings Inherited lipid disorders, including those causing extremes of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, or triglycerides were initially identified as monogenic traits, in which a single rare variant with large effect size is responsible for the phenotype. More recently, a polygenic basis for many lipid traits has also been identified. Patients with polygenic dyslipidemia can be identified through the use of polygenic risk scores (PRSs), which collapse information from a handful to several million genetic variants into a single metric. Summary PRSs for lipid traits may aid in the identification of the genetic basis for the lipid phenotype in individual patients, may provide additional information regarding the risk of cardiovascular disease, and could help in guiding therapeutic decision making. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.