OBESITY AND NUTRITION: Edited by Eric C. WestmanUsing a low-carbohydrate diet to treat obesity and type 2 diabetes mellitusWestman, Eric C.a; Yancy, William S. Jra,b,cAuthor Information aDivision of General Internal Medicine, Department of Medicine, Duke University Medical Center bCenter for Health Services Research in Primary Care, Durham Veterans Affairs Medical Center cDuke Diet and Fitness Center, Duke University Health System, Durham, North Carolina, USA Correspondence to Eric C. Westman, MD, MHS, Duke Keto Medicine Clinic, Duke University Health System, 4220 North Roxboro Street, Durham, NC 27704, USA. Tel: +1 919 620 4061; e-mail: [email protected] Current Opinion in Endocrinology & Diabetes and Obesity: October 2020 - Volume 27 - Issue 5 - p 255-260 doi: 10.1097/MED.0000000000000565 Buy Metrics Abstract Purpose of review This study will provide a narrative review of the history of the clinical use of low-carbohydrate diets and give a practical example of how to implement a low-carbohydrate diet, with an emphasis on deprescribing medications. Recent findings Low-carbohydrate diets have been used since the late 19th century to treat obesity and type 2 diabetes mellitus (T2DM). Recently, clinical research has validated the use of low-carbohydrate diets for individuals affected by obesity and T2DM, and these diets are included in several national clinical guidelines. Because medications are commonly used to treat hypertension and T2DM, special consideration must be made to monitor and reduce these medications to avoid overmedication. Clinic visits and home monitoring of blood pressure and glucose levels are important tools to alert clinicians that a reduction in medication levels may be indicated. Summary Low-carbohydrate diets have been utilized clinically for many years to treat obesity and T2DM and can be used alongside effective monitoring to safely deprescribe dispensable medications for these diseases. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.