THYROID: Edited by Angela M. LeungThyroid effects of amiodarone: clinical updateGoundan, Poorani N.; Lee, Stephanie L. Author Information Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts, USA Correspondence to Poorani N. Goundan, MBBS, Assistant Professor of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston Medical Center, 720 Harrison Avenue, DOB 8100, Boston, MA 02118, USA. Tel: +1 617 638 8530; fax: +1-617 638 7221; e-mail: [email protected] Current Opinion in Endocrinology & Diabetes and Obesity 27(5):p 329-334, October 2020. | DOI: 10.1097/MED.0000000000000562 Buy Metrics Abstract Purpose of review Amiodarone-induced thyroid dysfunction is well established and commonly encountered but is associated with several diagnostic and management challenges. The present review discusses recent evidence published related to the effects of amiodarone on the thyroid gland and thyroid function. Recent findings Retrospective studies to evaluate amiodarone-induced thyroid dysfunction in children show the occurrence of potential clinically significant changes within 2 weeks of amiodarone initiation that may not be detected if standard adult guidelines for thyroid hormone monitoring are followed. A small study evaluating beta-glucuronidase activity in amiodarone-induced thyrotoxicosis (AIT) demonstrated higher levels in patients with AIT type 2 compared to type 1. New data have suggested the incidence of agranulocytosis may be higher in patients on thionamides with AIT compared to hyperthyroidism because of other causes. In a small study, investigators demonstrated the use of a combination of intravenous and oral steroids to treat refractory AIT which needs to be evaluated in further controlled trials. Finally, recent data demonstrated a possible mortality benefit of surgery over medical therapy for AIT in patients with moderate to severe reduction in left ventricular ejection fraction. Summary Recent research regarding the prevalence, diagnosis, and management of amiodarone-induced thyroid dysfunction were reviewed. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.