PARATHYROIDS, BONE AND MINERAL METABOLISM: Edited by Vin TangprichaUpdates in vitamin D therapy in cystic fibrosisLe, Trang N.a,bAuthor Information aDepartment of Internal Medicine bDepartment of Pediatrics, Division of Endocrinology, Diabetes, and Metabolism, Virginia Commonwealth University, Richmond, Virginia, USA Correspondence to Trang N. Le, MD, Assistant Professor, Departments of Internal Medicine and Pediatrics, Division of Endocrinology, Diabetes, and Metabolism, Virginia Commonwealth University, P.O. Box 980111, Richmond, VA 23298, USA. Tel: +1 804 828 9696; fax: +1 804 828 8389; e-mail: [email protected] Current Opinion in Endocrinology & Diabetes and Obesity: December 2018 - Volume 25 - Issue 6 - p 361-365 doi: 10.1097/MED.0000000000000439 Buy Metrics Abstract Purpose of review To summarize recent developments the role of vitamin D and treatment of vitamin D deficiency in cystic fibrosis. Recent findings Although treatment of low vitamin D levels continues to be important for optimizing bone health in cystic fibrosis, increasing data on the extraskeletal effects of vitamin D are becoming available. Exploratory studies of vitamin D in modulation of respiratory and intestinal microbiomes, and the influence of vitamin D on the metabolomic signature of cystic fibrosis, suggest expanded roles for vitamin D in cystic fibrosis disease and treatment. Summary Emerging developments in cystic fibrosis regarding therapeutics and effects of vitamin D on bone health, inflammation, microbiome, and the metabolome are summarized. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.