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The catalytic role of iodine excess in loss of homeostasis in autoimmune thyroiditis

Duntas, Leonidas H.

Current Opinion in Endocrinology, Diabetes and Obesity: October 2018 - Volume 25 - Issue 5 - p 347–352
doi: 10.1097/MED.0000000000000425
THYROID: Edited by Lewis E. Braverman and Angela M. Leung

Purpose of review To review the latest developments concerning the role of iodine in the pathophysiology of autoimmune thyroiditis.

Recent findings Recent studies have provided evidence that in areas with excess iodine intake, increased incidence of autoimmune thyroiditis marked by high titers of thyroid peroxidase and thyroglobulin antibodies has occurred. Investigations in the NOD.H2h4 mouse, a strain prone to AIT, showed that they are better adapted to the Wolff–Chaikoff effect.

Summary To provide an overview of the studies conducted during the last few years implicating iodine in the development and manifestation of autoimmune thyroiditis.

Evgenidion Hospital, Unit of Endocrinology, Metabolism and Diabetes, Thyroid Section, University of Athens, Greece

Correspondence to Leonidas H. Duntas, MD, Professor of Endocrinology and Internal Medicine, Evgenideion Hospital, Unit of Endocrinology, Metabolism and Diabetes, University of Athens, 20 Papadiamantopoulou Street, Athens 11520, Greece. Tel: +30 210 674 8878; e-mail:

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