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Noonan syndrome: an update on growth and development

Yart, Armellea; Edouard, Thomasb,c

Current Opinion in Endocrinology & Diabetes and Obesity: February 2018 - Volume 25 - Issue 1 - p 67–73
doi: 10.1097/MED.0000000000000380
GROWTH AND DEVELOPMENT: Edited by Lynne L. Levitsky

Purpose of review To provide an update on recent developments on Noonan syndrome with a special focus on endocrinology, bone, and metabolism aspects. The key issues still to be resolved and the future therapeutic perspectives will be discussed.

Recent findings The discovery of the molecular genetic causes of Noonan syndrome and Noonan-syndrome-related disorders has permitted us to better understand the mechanisms underlying the different symptoms of these diseases and to establish genotype–phenotype correlations (in growth patterns for example). In addition to the classical clinical hallmarks of Noonan syndrome, new important aspects include decreased fertility in men, lean phenotype with increased energy expenditure and possible impact on carbohydrate metabolism/insulin sensitivity, and impaired bone health. Further clinical studies are needed to investigate the long-term impact of these findings and their possible interconnections. Finally, the understanding of the crucial role of RAS/mitogen-activated protein kinases dysregulation in the pathophysiology of Noonan syndrome allows us to devise new therapeutic approaches. Some agents are currently undergoing clinical trials in Noonan syndrome patients.

Summary On the last 10 years, our knowledge of the molecular basis and the pathophysiology of Noonan syndrome has greatly advanced allowing us to gain insight in all the aspects of this disease and to devise new specific therapeutic strategies.

aINSERM UMR1048, Institute of Cardiovascular and Metabolic Diseases (I2MC), Paul Sabatier University

bEndocrine, Bone Diseases, and Genetics Unit, Children's Hospital, Toulouse University Hospital

cINSERM UMR1043 – CNRS U5282, Physiopathology Center of Toulouse Purpan (CPTP), Paul Sabatier University, Toulouse, France

Correspondence to Thomas Edouard, Endocrine, Bone Diseases, and Genetics Unit, Children's Hospital, Toulouse University Hospital, 330 Avenue de Grande-Bretagne TSA 70034, 31059 Toulouse Cedex 9, France. Tel: +33 0 5 34 55 85 55; fax: +33 0 5 34 55 85 58; e-mail:

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