GROWTH AND DEVELOPMENT: Edited by Lynne L. LevitskyGenomic insights into growth and its disorders an updatede Bruin, Christiaan; Dauber, AndrewAuthor Information Cincinnati Center for Growth Disorders, Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA Correspondence to Andrew Dauber, MD, MMSc, Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Room T5-603, 3333 Burnet Ave, Cincinnati, OH 45229, USA. Tel: +1 513 803 7027; e-mail: [email protected] Current Opinion in Endocrinology & Diabetes and Obesity: February 2016 - Volume 23 - Issue 1 - p 51-56 doi: 10.1097/MED.0000000000000209 Buy Metrics Abstract Purpose of review This article provides an update of the most striking new developments in the field of growth genetics over the past 12 months. Recent findings A number of large genome-wide association studies have identified new genetic loci and pathways associated to human growth and adult height as well as related traits and comorbidities. New genetic causes of primordial dwarfism and several short stature syndromes have been elucidated. Moreover, a breakthrough finding of Xq26 microduplications as a cause of pituitary gigantism was made. Several new developments in imprinted growth-related genes (including the first human mutation in insulin-like growth factor II) and novel insights into the epigenetic regulation of growth have been reported. Summary Genomic investigations continue to provide new insights into the genetic basis of human growth as well as its disorders. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.