LIPIDS: Edited by Annabelle RodriguezPolyunsaturated fatty acid–phospholipid remodeling and inflammationRobichaud, Philippe Pierrea,b; Surette, Marc E.aAuthor Information aDepartment of Chemistry and Biochemistry, Université de Moncton, Moncton, New Brunswick bDepartment of Microbiology, Infectious Diseases and Immunology, Université Laval, Québec, Quebec, Canada Correspondence to Marc E. Surette, PhD, Department of Chemistry and Biochemistry, University of Moncton, Moncton, New Brunswick NB E1A 3E9, Canada. Tel: +1 506 858 4293; fax: +1 506 858 4541; e-mail: email@example.com Current Opinion in Endocrinology, Diabetes and Obesity: April 2015 - Volume 22 - Issue 2 - p 112-118 doi: 10.1097/MED.0000000000000138 Buy Metrics Abstract Purpose of review To highlight some of the recent advances related to the control of polyunsaturated fatty acid (PUFA) incorporation and remodeling in membrane glycerophospholipids in inflammatory cells. Recent findings Several enzymes have recently been identified that are associated with the control of PUFA incorporation and remodeling into membrane phospholipids and their release. The functional roles of the different enzyme isotypes in the control of PUFA availability for lipid mediator biosynthesis and cell signaling are only now being established. The expression of specific acyl–CoA synthetase, lysophospholipid acyltransferase and phospholipase A2 isotypes has recently been shown to have an impact on membrane PUFA content, on the production of lipid mediators and on inflammation. Summary A better understanding of the complex processes associated with the control PUFA remodeling in membrane phospholipids may lead to the discovery of new therapeutic targets for the treatment of inflammatory diseases. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.