NEUROENDOCRINOLOGY: Edited by Whitney WoodmanseeMetabolic effects of sleep disruption, links to obesity and diabetesNedeltcheva, Arlet V.; Scheer, Frank A.J.L. Author Information Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham & Women's Hospital, Boston, Massachusetts, USA Correspondence to Arlet V. Nedeltcheva, MD, Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Brigham & Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA. Tel: +1 617 732 8104; fax: +617 732 7337; e-mail: [email protected] Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.co-endocrinology.com). Current Opinion in Endocrinology & Diabetes and Obesity: August 2014 - Volume 21 - Issue 4 - p 293-298 doi: 10.1097/MED.0000000000000082 Buy SDC Metrics Abstract Purpose of review To highlight the adverse metabolic effects of sleep disruption and to open ground for research aimed at preventive measures. This area of research is especially relevant given the increasing prevalence of voluntary sleep curtailment, sleep disorders, diabetes, and obesity. Recent findings Epidemiological studies have established an association between decreased self-reported sleep duration and an increased incidence of type 2 diabetes (T2D), obesity, and cardiovascular disease. Experimental laboratory studies have demonstrated that decreasing either the amount or quality of sleep decreases insulin sensitivity and decreases glucose tolerance. Experimental sleep restriction also causes physiological and behavioral changes that promote a positive energy balance. Although sleep restriction increases energy expenditure because of increased wakefulness, it can lead to a disproportionate increase in food intake, decrease in physical activity, and weight gain. Summary Sleep disruption has detrimental effects on metabolic health. These insights may help in the development of new preventive and therapeutic approaches against obesity and T2D based on increasing the quality and/or quantity of sleep. https://links.lww.com/COE/A6 Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.