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Update on endocrine and metabolic therapy-related late effects observed in survivors of childhood neoplasia

Chemaitilly, Wassima,b; Hudson, Melissa M.b,c

Current Opinion in Endocrinology, Diabetes and Obesity: February 2014 - Volume 21 - Issue 1 - p 71–76
doi: 10.1097/MED.0000000000000029
GROWTH AND DEVELOPMENT: Edited by Lynne L. Levitsky

Purpose of review To provide a summary of the most recent research pertaining to the endocrine and metabolic complications observed in childhood cancer survivors.

Recent findings Data on prevalence and risk associations are increasingly available from large cohorts of childhood cancer survivors. New directions in research include novel risk-prediction strategies and the study of genetic predisposition.

Summary Endocrine complications are observed in more than 50% of adult childhood cancer survivors. Some continue to develop decades following cancer treatment exposures. The present review provides a summary of the most recent outcomes research pertaining to growth, thyroid, gonadal–reproductive, bone and body composition with emphasis on new directions and challenges in each area.

aDepartment of Pediatric Medicine – Division of Endocrinology

bDepartment of Epidemiology and Cancer Control

cDepartment of Oncology-Division of Survivorship3, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

Correspondence to Wassim Chemaitilly, MD, Division of Endocrinology, MS 737, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Tel: +1 901 595 3824; fax: +1 901 595 4613; e-mail:

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins