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Duodenal–jejunal bypass liners: outcomes in glycaemic control and weight loss

Neff, Karl J.a; Miras, Alex D.b; le Roux, Carela,b

Current Opinion in Endocrinology, Diabetes and Obesity: October 2013 - Volume 20 - Issue 5 - p 420–428
doi: 10.1097/
OBESITY AND NUTRITION: Edited by Caroline M. Apovian and Jeffrey I. Mechanick

Purpose of review Duodenal–jejunal bypass liners (DJBLs) are a novel therapy with potential treating a range of metabolic diseases. This review discusses the weight loss and glycaemic improvements observed following the use of the DJBL.

Recent findings We summarize the evidence for the clinical application of DJBL to date. Within this, we outline the evidence available on the mechanisms of the observed effects.

Summary Based on the most recent trials, we cannot fully mimic the clinical or physiological effects of bariatric surgery with this device, but we are getting closer.

aDiabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland

bInvestigative Science, Imperial College London, London, UK

Correspondence to Professor Carel le Roux, Diabetes Complications Research Centre, Conway Institiute, School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland. Tel: +353 17166831; e-mail:

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins