LIPIDS: Edited by Annabelle RodriguezThe effect of androgens on lipidsMonroe, Anne K.; Dobs, Adrian S.Author Information aDivision of General Internal Medicine bDivision of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Maryland, USA Correspondence to Adrian S. Dobs, MD, MHS, Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument Street, Suite 328, Baltimore, MD 21205, USA. Tel: +1 443 287 4000; fax: +1 410 955 8172; e-mail: [email protected] Current Opinion in Endocrinology & Diabetes and Obesity: April 2013 - Volume 20 - Issue 2 - p 132-139 doi: 10.1097/MED.0b013e32835edb71 Buy Metrics Abstract Purpose of review To review recent data concerning the relationship between endogenous testosterone and lipids as well as testosterone replacement therapy and lipids. To describe the effects of sex hormones on cardiovascular disease (CVD) that may act via serum lipids. Recent findings Low endogenous testosterone is associated with high low-density lipoprotein and low high-density lipoprotein in both cross-sectional and prospective observational studies. Exogenous testosterone administration is associated with decreased high-density lipoprotein coupled with beneficial decreases in low-density lipoprotein and total cholesterol. The overall impact of testosterone administration on CVD is still unclear, with mixed safety results from recent randomized controlled trials. Summary There may be CVD risk reduction benefits, including an improved lipid profile, from testosterone administration in hypogonadal men. The overall effect of testosterone on CVD risk has not been definitively determined. Copyright © 2013 Wolters Kluwer Health, Inc. All rights reserved.