Purpose of review
To review recent data concerning the relationship between endogenous testosterone
as well as testosterone
replacement therapy and lipids
. To describe the effects of sex hormones on cardiovascular disease
(CVD) that may act via serum lipids
Low endogenous testosterone
is associated with high low-density lipoprotein and low high-density lipoprotein in both cross-sectional and prospective observational studies. Exogenous testosterone
administration is associated with decreased high-density lipoprotein coupled with beneficial decreases in low-density lipoprotein and total cholesterol. The overall impact of testosterone
administration on CVD is still unclear, with mixed safety results from recent randomized controlled trials.
There may be CVD risk reduction benefits, including an improved lipid profile, from testosterone
administration in hypogonadal men. The overall effect of testosterone
on CVD risk has not been definitively determined.