Institutional members access full text with Ovid®

Share this article on:

Radioactive iodine therapy

Lee, Stephanie L.

Current Opinion in Endocrinology, Diabetes and Obesity: October 2012 - Volume 19 - Issue 5 - p 420–428
doi: 10.1097/MED.0b013e328357fa0c
THYROID: Edited by Lewis E. Braverman

Purpose of review Review of the management decisions that must be made by the endocrinologist during the use of radioactive iodine (RAI) therapy of hyperthyroidism and differentiated thyroid cancer.

Recent findings Since the 1940s radioactive 131I (RAI) therapy has been a major component of the treatment of hyperthyroidism and differentiated thyroid cancer. RAI is the most common definitive treatment of hyperthyroidism. Pretherapy decisions including use of antithyroid medication and low-iodine diet will be discussed with the relevant supportive literature. The method of semi-quantitative calculation used for RAI treatment of hyperthyroidism will be described. Evidence-based guideline for the management of differentiated thyroid cancer by the American Thyroid Association, new drug development and recent randomized controlled trials have changed current practice of how RAI is used for remnant ablation and adjuvant therapy of differentiated thyroid cancer.

Summary RAI is a common tool for the endocrinologist in the management of hyperthyroidism and differentiated thyroid cancer. Review of the management decisions and practice of RAI therapy will educate the endocrinologist of the literature supporting current RAI use in hyperthyroidism and new developments in limiting the radiation exposure to the patients with differentiated thyroid cancer.

Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA

Correspondence to Stephanie L. Lee, MD, PhD, Associate Professor of Medicine, Boston University School of Medicine, Boston Medical Center, 88 E. Newton Street, Evans-201, Boston, MA 02118, USA. Tel: +1 617 638 8530; fax: +1 617 638 7221; e-mail:

© 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins