THYROID: Edited by Lewis E. BravermanIodine-induced thyroid dysfunctionLeung, Angela M.; Braverman, Lewis E. Author Information Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA Correspondence to Angela M. Leung, MD, MSc, Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, 88 East Newton Street, Evans 201, Boston, MA 02118, USA. Tel: +1 617 638 8521; fax: +1 617 638 7221; e-mail: [email protected] Current Opinion in Endocrinology & Diabetes and Obesity 19(5):p 414-419, October 2012. | DOI: 10.1097/MED.0b013e3283565bb2 Buy Metrics Abstract Purpose of review To summarize the mechanisms of iodine-induced hypothyroidism and hyperthyroidism, identify the risk factors for thyroid dysfunction following an iodine load, and summarize the major sources of excess iodine exposure. Recent findings Excess iodine is generally well tolerated, but individuals with underlying thyroid disease or other risk factors may be susceptible to iodine-induced thyroid dysfunction following acute or chronic exposure. Sources of increased iodine exposure include the global public health efforts of iodine supplementation, the escalating use of iodinated contrast radiologic studies, amiodarone administration in vulnerable patients, excess seaweed consumption, and various miscellaneous sources. Summary Iodine-induced thyroid dysfunction may be subclinical or overt. Recognition of the association between iodine excess and iodine-induced hypothyroidism or hyperthyroidism is important in the differential diagnosis of patients who present without a known cause of thyroid dysfunction. Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.