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Closed-loop artificial pancreas: current studies and promise for the future

Weinzimer, Stuart A.

Current Opinion in Endocrinology & Diabetes and Obesity: April 2012 - Volume 19 - Issue 2 - p 88–92
doi: 10.1097/MED.0b013e3283514e6b

Purpose of review The availability of glucose sensors and insulin pumps has enabled the development of devices and software to partially or completely automate insulin delivery. Over the last 2 years, the number of centers developing and evaluating such systems, as well as the number of reports of these studies in the literature, have expanded dramatically. The purpose of this review is to highlight the progress along multiple fronts to develop automated systems to improve control of type 1 diabetes.

Recent findings Multiple approaches, including automated suspension for actual or impending hypoglycemia, automated augmentation for hyperglycemia, as well as hybrid and full closed-loop control, are in parallel development. So far, early hypoglycemia prevention studies and small inpatient feasibility studies have demonstrated the potential for reducing hypoglycemia and improving overall diabetes control.

Summary Current sensors, pumps, and control algorithms show promise for use in a closed-loop system but have been limited to inpatient studies. The next phase of development should focus on their evaluation in controlled short-term outpatient safety and efficacy trials.

Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA

Correspondence to Stuart A Weinzimer, MD, Yale University School of Medicine, Department of Pediatrics, P.O. Box 208064, New Haven, CT 06520-8064, USA. Tel: +1 203 785 7924; fax: +1 203 737 2829; e-mail:

© 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins