Neuroendocrinology: Edited by William H. LudlamThe diagnosis and treatment of growth hormone deficiency in adultsClemmons, David RAuthor Information Division of Endocrinology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Correspondence to David R. Clemmons, CB# 7170, 8025 Burnett Womack, Division of Endocrinology, University of North Carolina, Chapel Hill, NC 27599-7170, USA Tel: +1 919 966 4735; fax: +1 919 966 6025; e-mail: [email protected] Current Opinion in Endocrinology, Diabetes and Obesity: August 2010 - Volume 17 - Issue 4 - p 377-383 doi: 10.1097/MED.0b013e32833b6bc7 Buy Metrics Abstract Purpose of review This review summarizes the recent published information regarding efficacy and complications of growth hormone replacement therapy. Several recent reports have monitored patients for periods of up to 10 years. Additionally, a consensus conference has been held regarding needed improvements in diagnostic testing and the recommendations of consensus panels regarding diagnostic criteria and laboratory test utilization are summarized. Recent findings Long-term studies show growth hormone can be administered safely and that muscle strength and function as well as lipoprotein abnormalities and low-bone mineral density show sustained improvement over extended periods of time. The complications that occur are generally dose-dependent and once attenuated do not tend to recur. Long-term safety studies regarding improvement in cardiovascular mortality and/or worsening prognosis for patients who develop malignancies are available only in the form of observational studies and randomized controlled long-term trial information is not yet available. The studies reported provide a means for clinicians to ascertain the patients who are likely to derive the greatest benefit from growth hormone when the appropriate diagnostic testing and treatment paradigms are utilized. Summary The studies that are summarized provide useful information for assessing the response to treatment, selecting patients who are candidates for long-term replacement therapy and for selecting those in whom the need for therapy may need to be reassessed. © 2010 Lippincott Williams & Wilkins, Inc.