Gastrointestinal hormones: Edited by H. Christian WeberGastrointestinal peptides and regulation of gastric acid secretionvon Rosenvinge, Erik C; Raufman, Jean-PierreAuthor Information Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore VA Medical Center, Baltimore, Maryland, USA Correspondence to Erik von Rosenvinge, MD, Assistant Professor of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore VA Medical Center, 22 S. Greene Street, N3W62, Baltimore, MD 21201, USA Tel: +1 410 605 7000, ext. 5260; fax: +1 410 328 8315; e-mail: [email protected] Current Opinion in Endocrinology, Diabetes and Obesity: February 2010 - Volume 17 - Issue 1 - p 40-43 doi: 10.1097/MED.0b013e32833304e1 Buy Metrics Abstract Purpose of review Update on the role of gastrointestinal peptides in regulating gastric acid secretion. Recent findings A novel transgenic mouse that expresses the entire human gastrin gene locus in G-cells of gastrin-null mice will facilitate investigation of gastrin gene regulatory elements. Isolation of a highly homogeneous population of G-cells permits the elucidation of stimulatory and inhibitory ligands without the confounding presence of other neuroendocrine cells. The use of somatostatin receptor knockout mice demonstrated the plasticity of gastric acid regulatory mechanisms and compensation by upregulation of the galanin pathway which inhibits secretion by enterochromaffin-like cells. The importance of adenosine in regulating somatostatin release was shown using adenosine receptor knockout mice. Summary The importance of gastrointestinal peptides for regulating gastric acid is evident. Ongoing investigations will characterize the mechanisms underlying actions of these agents on gastric acid secretion, particularly with regard to their combinatorial effects and interplay with other acid-regulating pathways. © 2010 Lippincott Williams & Wilkins, Inc.