Cardiopulmonary monitoringTranspulmonary dilution-derived extravascular lung water as a measure of lung edemaKhan, Saheed; Trof, Ronald J; Groeneveld, AB JohanAuthor Information Department of Intensive Care, VU University Medical Center, Amsterdam, The Netherlands Correspondence to Professor A.B.J. Groeneveld, MD, PhD, FCCP, FCCM, Department of Intensive Care, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands Tel: +31 20 4444178; fax: +31 20 4442392; e-mail: [email protected] Current Opinion in Critical Care: June 2007 - Volume 13 - Issue 3 - p 303-307 doi: 10.1097/MCC.0b013e32811d6ccd Buy Metrics Abstract Purpose of review This review highlights current insights concerning the (measurement of) extravascular lung water as an index of pulmonary edema, by transpulmonary dilution techniques. The focus is on the applicability of the technique at the bedside in monitoring critically ill patients. Recent findings Several (animal) studies have been performed to validate the technique by postmortem gravimetry in different conditions. Moreover, recent clinical data emphasize the utility of the thermodilution-derived extravascular lung water, its contribution to the clinical manifestations of acute lung injury/acute respiratory distress syndrome, its response to treatment aimed at edema prevention or resolution, and as a prognostic parameter. Summary The thermodilution-derived extravascular lung water is a useful adjunct to assess lung vascular injury, cardiogenic edema and overhydration and to guide treatment in critically ill patients. The effects on morbidity and mortality of this approach need to be studied further. © 2007 Lippincott Williams & Wilkins, Inc.