CARDIOGENIC SHOCK: Edited by Fabio GuarracinoPathophysiology of cardiogenic shockBertini, Pietro; Guarracino, Fabio Author Information Cardiothoracic and Vascular Anesthesia and Intensive Care, Department of Anesthesia and Critical Care Medicine, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy Correspondence to Fabio Guarracino, MD, Department of Anesthesia and Critical Care Medicine, Cardiothoracic and vascular anesthesia and intensive care, Azienda Ospedaliero Universitaria Pisana, Via Paradisa 2, 56123 Pisa, Italy. Tel: +39 050995244; e-mail: [email protected] Current Opinion in Critical Care 27(4):p 409-415, August 2021. | DOI: 10.1097/MCC.0000000000000853 Buy Metrics Abstract Purpose of review We describe the pathophysiology of cardiogenic shock (CS), from the main pathways to the inflammatory mechanisms and the proteomic features. Recent findings Although the classical pathophysiological pathways underlying CS, namely reduced organ perfusion due to inadequate cardiac output and peripheral vasoconstriction, have been well-established for a long time, the role of macro-and micro-hemodynamics in the magnitude of the disease and its prognosis has been investigated extensively only over the last few years. Moreover, to complete the complex picture of CS pathophysiology, the study of cytokine cascade, inflammation, and proteomic analysis has been addressed recently. Summary Understanding the pathophysiology of CS is important to treat it optimally. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.