Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Fluids and hyperosmolar agents in neurocritical care

an update

Farrokh, Saliaa,b,*; Cho, Sung-Minb,*; Suarez, Jose I.b

Current Opinion in Critical Care: April 2019 - Volume 25 - Issue 2 - p 105–109
doi: 10.1097/MCC.0000000000000585
NEUROSCIENCE: Edited by Mauro Oddo

Purpose of review To discuss recent updates in fluid management and use of hyperosmolar therapy in neurocritical care.

Recent findings Maintaining euvolemia with crystalloids seems to be the recommended fluid resuscitation for neurocritical care patients. Buffered crystalloids have been shown to reduce hyperchloremia in patients with subarachnoid hemorrhage without causing hyponatremia or hypo-osmolality. In addition, in patients with traumatic brain injury, buffered solutions reduce the incidence of hyperchloremic acidosis but are not associated with intracranial pressure (ICP) alteration. Both mannitol and hypertonic saline are established as effective hyperosmolar agents to control ICP. Both agents have been shown to control ICP, but their effects on neurologic outcomes are unclear. A recent surge in preference for using hypertonic saline as a hyperosmolar agent is based on few studies without strong evidence.

Summary Fluid resuscitation with crystalloids seems to be reasonable in this setting although no recommendations can be made regarding type of crystalloids. Based on current evidence, elevated ICP can be effectively reduced by either hypertonic saline or mannitol.

aDepartment of Pharmacy, Division of Critical Care and Surgery, Johns Hopkins Hospital

bDivision of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery Johns Hopkins School of Medicine, Baltimore Maryland. USA

Correspondence to Jose I. Suarez, MD, Professor and Director, Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, Johns Hopkins University School of Medicine, 1800 Orleans St Sheikh Zayed Building, 3014C Baltimore, MD 21287, USA. Tel: +1 410 955 7481; e-mail:

Copyright © 2019 YEAR Wolters Kluwer Health, Inc. All rights reserved.