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Antibiotic treatment of hospital-acquired pneumonia

is it different from ventilator-associated pneumonia?

Niederman, Michael S.

Current Opinion in Critical Care: October 2018 - Volume 24 - Issue 5 - p 353–360
doi: 10.1097/MCC.0000000000000531
INFECTIOUS DISEASES: Edited by Antoni Torres

Purpose of review Hospital-acquired pneumonia (HAP) is a form of nosocomial pneumonia, distinct from ventilator-associated pneumonia (VAP). This review compares HAP and VAP, highlighting differences in natural history, risk factors, and bacteriology that necessitate a different approach to the therapy of HAP, compared with VAP.

Recent findings HAP can arise out of the ICU, or in the ICU, and can lead to severe illness, including the need for intubation and mechanical ventilation. New American and European nosocomial pneumonia guidelines make therapy recommendations for HAP. The American guidelines recommend broader spectrum therapy than the European guidelines, but recent studies support the idea that not all HAP patients need antipseudomonal therapy. When the American guideline approach to HAP has been studied, it led to both overtreatment and inappropriate therapy for the identified pathogens. An algorithm, modified from the European guideline, proposes an approach to therapy that necessitates dual antipseudomonal therapy in less than 25% of all HAP patients.

Summary Although more prospective therapy trials of HAP are needed, based on currently available data, it is possible to use an approach that provides appropriate therapy without the overuse of broad-spectrum therapy.

Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, New York, USA

Correspondence to Michael S. Niederman, MD, Professor of Clinical Medicine, Associate Chief and Clinical Director, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, 425 East 61st Street, New York, NY 10065, USA. Tel: +1 646 962 2333; fax: +1 646 962 0330; e-mail:

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