GASTROINTESTINAL SYSTEM: Edited by Stephen A. McClaveAutophagy: should it play a role in ICU management?Rosenthal, Martin D.a; Carrott, Philb; Moore, Frederick A.a Author Information aDepartment of Surgery, University of Florida, Gainesville, Florida bSection of Thoracic Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA Correspondence to Martin D. Rosenthal, MD, College of Medicine, Department of Surgery, University of Florida, 1600 SW Archer Road, Gainesville, FL 32608, USA. E-mail: [email protected] Current Opinion in Critical Care: April 2018 - Volume 24 - Issue 2 - p 112-117 doi: 10.1097/MCC.0000000000000486 Buy Metrics Abstract Purpose of review This review is to discuss the role of autophagy in the critically ill patient population. As the understanding of autophagy continues to expand and evolve, there are certain controversies surrounding whether intensivist should allow the benefit of autophagy to supersede gold standard of insulin therapy or early nutritional support. Recent findings The review is relevant as the current literature seems to support under-feeding patients, and perhaps the reason these studies were positive could be prescribed to the mechanisms of autophagy. It is well understood that autophagy is a physiologic response to stress and starvation, and that the inducible form could help patients with end-organ dysfunction return to homeostasis. Summary The jury is still out as to how autophagy will play into clinical practice as we review several gold standard therapies for the critically ill. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.