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Muscle metabolism

Tardif, Nicolasa,b; Grip, Jonathana,b; Rooyackers, Olava,b

Current Opinion in Critical Care: August 2017 - Volume 23 - Issue 4 - p 264–268
doi: 10.1097/MCC.0000000000000426
METABOLIC SUPPORT: Edited by Kenneth B. Christopher

Purpose of review To review the recent findings on metabolic derangements leading to loss of muscle mass and function.

Recent findings Several recent studies investigated methods to assess muscle mass and function and its clinical relevance. These are also included. A few studies confirm that a low muscle mass is related to a worse outcome but also a compromised muscle function at discharge is related to long-term survival. A low quality of muscle assessed by the density of muscle from a computed tomography scan is related to mortality. For the metabolic derangements, a compromised handling of calcium is present in muscle of animal models and might be causing a decreased muscle function in patients. Transcriptomics analyses of muscle post-ICU indicated an upregulation of regenerative pathways, but still muscle mass is not recovering in most patients. This could be due to an impairment regenerative capacity due to satellite cells dysfunction.

Summary Muscle mass and function are related to outcome. New finding show that not only muscle mass but also muscle quality is important, that a compromised handling of calcium might be involved in muscle weakness and that regaining muscle could be compromised due to a defective regenerative capacity of satellite cells.

aAnesthesiology and Intensive Care, CLINTEC, Karolinska Institutet

bPerioperative Medicine and Intensive Care, Karolinska University Hospital, Huddinge, Sweden

Correspondence to Olav Rooyackers, Perioperative Medicine and Intensive Care, Karolinska University Hospital, 14186 Huddinge, Sweden. E-mail:

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