Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Biomarkers in acute respiratory distress syndrome

Binnie, Alexandraa; Tsang, Jennifer L.Y.b; dos Santos, Claudia C.c,d

Current Opinion in Critical Care: February 2014 - Volume 20 - Issue 1 - p 47–55
doi: 10.1097/MCC.0000000000000048
RESPIRATORY SYSTEM: Edited by Peolo Pelosi

Purpose of review The article provides an overview of efforts to identify and validate biomarkers in acute respiratory distress syndrome (ARDS) and a discussion of the challenges confronting researchers in this area.

Recent findings Although various putative biomarkers have been investigated in ARDS, the data have been largely disappointing and the ‘troponin’ of ARDS remains elusive. Establishing a relationship between measurable biological processes and clinical outcomes is vital to advancing clinical trials in ARDS and expanding our arsenal of treatments for this complex syndrome.

Summary This article summarizes the current status of ARDS biomarker research and provides a framework for future investigation.

aDepartment of Medicine, St Joseph's Health Centre, Toronto

bDepartment of Critical Care Medicine, McMaster University, Hamilton

cKeenan and Li Ka Shing Knowledge Institute of Saint Michael's Hospital

dInstitute of Medical Sciences and Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Correspondence to Dr dos Santos, Critical Care Medicine and Clinician Scientist, Assistant Professor of Medicine, St. Michael's Hospital/University of Toronto, 30 Bond Street, Toronto, ON M5B 1WB, Canada. Tel: +1 416 946 0420; e-mail:

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins