EMERGENCIES: Edited by Alan E. JonesAnaphylaxisDe Bisschop, Marie-Bénédictea,b; Bellou, Abdelouahaba,cAuthor Information aEmergency Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium bEmergency Medicine Department, University Hospital of Rennes cHead of Emergency Medicine Department, University Hospital of Rennes, Rennes, France Correspondence to Abdelouahab Bellou, CHU de Rennes, 2 rue Henry Le Guilloux, Rennes 35000, France. E-mail: [email protected] Current Opinion in Critical Care: August 2012 - Volume 18 - Issue 4 - p 308-317 doi: 10.1097/MCC.0b013e3283557a63 Buy Metrics Abstract Purpose of review This article aims to make a review of the up-to-date knowledge on anaphylaxis and outline the recent advances on pathophysiology, diagnosis, and management of anaphylaxis. Recent findings New data confirm the increase in prevalence of anaphylaxis and emphasize immunopathologic mechanisms. However, anaphylaxis is often underdiagnosed and guidelines are poorly applied, particularly in emergency departments. Summary An improvement of rapid diagnosis and treatment combined with education of population will decrease mortality and morbidity of anaphylaxis. © 2012 Lippincott Williams & Wilkins, Inc.