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Fructose malabsorption syndrome

Putkonen, Leenaa; Yao, Chu K.b; Gibson, Peter R.b

Current Opinion in Clinical Nutrition and Metabolic Care: July 2013 - Volume 16 - Issue 4 - p 473–477
doi: 10.1097/MCO.0b013e328361c556
CARBOHYDRATES: Edited by Luc Tappy and Bettina Mittendorfer

Purpose of review Fructose malabsorption is associated with gastrointestinal symptoms. This review examines new findings on the physiology, assessment and therapy of fructose malabsorption in functional gastrointestinal disorders.

Recent findings Additional GLUT transport mechanisms that regulate fructose absorption might be involved in symptom adaptation to high-fructose diets. Although glucose is known to facilitate fructose absorption, erythritol promotes malabsorption. The methodologies of fructose breath testing and its clinical utility have been questioned by findings of unrealistic testing dose and poor reproducibility. Although fructose restriction appears to benefit children with functional abdominal pain, fructose restriction itself may not be the key player. In irritable bowel syndrome, fructose restriction within a diet low in other fermentable carbohydrates fermentable, oligosaccharide, disaccharide monosaccharide and polyols produced good symptom control compared with habitual diet, but such therapy resulted in significantly reduced bifidobacteria. Fructose absorption and subsequently, abdominal pain and nausea are improved by a novel enzyme therapy that converts fructose to glucose for absorption.

Summary New insights into factors affecting fructose absorption may have therapeutic applications. Doubts surrounding clinical utility of fructose breath testing are emerging. Although restriction of fructose and other fermentable, oligosaccharide, disaccharide monosaccharide and polyols have efficacy for functional gastrointestinal symptoms, potentially negative effects on microbiota deserve attention.

aSchool of Health Sciences, University of Tampere, Finland

bDepartment of Gastroenterology, Central Clinical School, Monash University, Alfred Health, Melbourne, Victoria, Australia

Correspondence to Professor Peter Gibson, Department of Gastroenterology, Monash University, The Alfred Centre, Level 6/99 Commercial Rd, Prahran, 3004 VIC, Australia. Tel: +613 9903 0189; fax: +613 9903 0556; e-mail:

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins