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Is nutrition important to postpone frailty?

Kelaiditi, Eirinia; Guyonnet, Sophiea,b; Cesari, Matteoa,b,c

Current Opinion in Clinical Nutrition & Metabolic Care: January 2015 - Volume 18 - Issue 1 - p 37–42
doi: 10.1097/MCO.0000000000000129
AGEING: BIOLOGY AND NUTRITION: Edited by Tommy Cederholm and John E. Morley

Purpose of review The purpose of the present study is to provide an updated, systematic review of the recent literature on whether nutrition is important to postpone frailty.

Recent findings A systematic review of recent literature (past 12 months) identified nine studies (eight of which using a cross-sectional design) exploring the relationship between nutrition and frailty. A single randomized controlled double-blind trial was published. However, being a pilot study, it was characterized by a relatively small sample size, short follow-up length (i.e., 6 months), and low statistical power. Notably, available evidence shows considerable variability in participants’ selection and assessment methods, rendering difficult direct comparisons. Size effects or magnitude of associations across the different studies cannot also be determined.

Summary There is a need for long-term, adequately powered, randomized controlled trials examining nutrition (alone and/or in combination with other appropriate interventions) as a means for postponing frailty in older persons.

aGérontopôle, Centre Hospitalier Universitaire de Toulouse


cUniversité de Toulouse III-Paul Sabatier, Toulouse, France

Correspondance to Eirini Kelaiditi, PhD, Institut du Vieillissement, Gérontopôle, Université de Toulouse III-Paul Sabatier, 37 Allées Jules Guesde, 31000 Toulouse, France. Tel: +33 (0)5 61 14 56 68; e-mail:

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