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Current World Literature

Current Opinion in Clinical Nutrition & Metabolic Care: January 2013 - Volume 16 - Issue 1 - p 109–117
doi: 10.1097/MCO.0b013e32835c445e

This bibliography is compiled by clinicians from the relevant journals scanned by this publication. It is based on the literature regularly pulled into our database from OvidSP (articles are generally added to the database about two and a half months after publication). In addition, the bibliography contains every paper annotated by reviewers; these references were obtained from a variety of bibliographic databases and published between the beginning of the review period and the time of going to press. The bibliography has been grouped into topics that relate to the reviews in this issue.

▪ Papers considered by the reviewers to be of special interest

▪▪ Papers considered by the reviewers to be of outstanding interest

The number in square brackets following a selected paper, e.g. [7], refers to its number in the annotated references of the corresponding review.

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Ageing: biology and nutrition

Sex hormones and sarcopenia in older persons

Review: (pp. 3–13)

▪. Baker WL, Karan S, Kenny AM. Effect of dehydroepiandrosterone on muscle strength and physical function in older adults: a systematic review. J Am Geriatr Soc 2011; 59:997–1002. [14]

▪. Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci 2012 [Epub ahead of print]. [35]

▪▪. Bhasin S, Travison TG, Storer TW, et al. Effect of testosterone supplementation with and without a dual 5(-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial. J Am Med Assoc 2012; 307:931–939. [33]

Brotto M. Aging, sarcopenia and store-operated calcium entry A common link? Cell Cycle 2011; 10:4201–4202.

Candow DG. Sarcopenia: current theories and the potential beneficial effect of creatine application strategies. Biogerontology 2011; 12:273–281.

Cederholm TE, Bauer JM, Boirie Y, Schneider SM, et al. Toward a Definition of Sarcopenia. Clin Geriatr Med 2011; 27:341.

▪▪. Dubois V, Laurent M, Boonen S, et al. Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions. Cell Mol Life Sci 2012; 69:1651–1667. [10]

Giannoulis MG, Martin FC, Nair KS, Umpleby AM, et al. Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones? Endocr Rev 2012; 33:314–377.

▪▪. Grossmann MJ. Low testosterone in men with type 2 diabetes: significance and treatment. J Clin Endocrinol Metab 2011; 96:2341–2353. [12]

Jackson JR, Ryan MJ, Alway SE. Long-Term Supplementation With Resveratrol Alleviates Oxidative Stress but Does Not Attenuate Sarcopenia in Aged Mice. J Gerontol Ser A-Biol Sci Med Sci 2011; 66:751–764.

▪. Maggio M, Nicolini F, Cattabiani C, et al. Effects of testosterone supplementation on clinical and rehabilitative outcomes in older men undergoing on-pump CABG. Contemp Clin Trials 2012; 33:730–738 [42]

▪. Maggio M, Ceda GP, Lauretani F, et al. Gonadal status and physical performance in older men. Aging Male 2011; 14:42–47. [27]

▪. Maggio M, Ceda GP, Lauretani F, et al. Magnesium and anabolic hormones in older men. Int J Androl 2011; 34:e594–e600. [37]

Morley JE. Sarcopenia in the elderly. Fam Pr 2012; 29:i44–i48.

Ogawa K, Kim HK, Shimizu T, Abe S, et al. Plasma heat shock protein 72 as a biomarker of sarcopenia in elderly people. Cell Stress Chaperones 2012; 17:349–359.

▪. Piantadosi C, Visvanathan R, Naganathan V, et al. The effect of testosterone and a nutritional supplement on hospital admissions in under-nourished, older people. BMC Geriatr 2011; 11:66. [39]

Rosenberg IH. Sarcopenia: Origins and Clinical Relevance. Clin Geriatr Med 2011; 27:337.

▪. Sakuma K, Yamaguchi A. Sarcopenia and age-related endocrine function. Int J Endocrinol 2012; 127362. [04]

▪▪. Sheffield-Moore M, Dillon EL, Casperson SL, et al. A randomized pilot study of monthly cycled testosterone replacement or continuous testosterone replacement versus placebo in older men. J Clin Endocrinol Metab 2011; 96:E1831–E1837. [34]

▪▪. Travison TG, Basaria S, Storer TW, et al. Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation. J Gerontol A Biol Sci Med Sci 2011; 66:1090–1099. [23]

Visser M, Schaap LA. Consequences of Sarcopenia. Clin Geriatr Med 2011; 27:387.

Walrand S, Guillet C, Salles J, Cano N, et al. Physiopathological Mechanism of Sarcopenia. Clin Geriatr Med 2011; 27:365.

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Review: (pp. 14–20)

Addison O, La Stayo PC, Dibble LE, Marcus RL. Inflammation, Aging, and Adiposity: Implications for Physical Therapists. J Geriatr Phys Ther 2012; 35:86–94.

▪▪. Biagi E, Candela M, Fairweather-Tait S, et al. Aging of the human metaorganism: the microbial counterpart. Age 2012; 34:247–267. [37]

▪. Bonafè M, Storci G, Franceschi C. Inflamm-aging of the stem cell niche: Breast cancer as a paradigmatic example: Breakdown of the multishell cytokine network fuels cancer in aged people. Bioessays 2011; 34:40–49. [27]

Capettini LSA, Montecucco F, Mach F, Stergiopulos N, et al. Role of Renin-Angiotensin System in Inflammation, Immunity and Aging. Curr Pharm Design 2012; 18: 963–970.

Chang SS, Weiss CO, Xue QL, Fried LP. Association between inflammatory-related disease burden and frailty: Results from the Women's Health and Aging Studies (WHAS) I and II. Arch Gerontol Geriatr 2011; 54:9–15.

▪. Claesson MJ, Jeffery IB, Conde S, et al. Gut microbiota composition correlates with diet and health in the elderly. Nature 2012; 488:178–184. [34]

▪. Gregor MF, Hotamisligil GkS. Inflammatory mechanisms in obesity. Ann Rev Immunol 2011; 29:415–445. [29]

Kim JM, Uehara Y, Choi YJ, Ha YM, et al. Mechanism of attenuation of pro-inflammatory Ang II-induced NF-kappa B activation by genistein in the kidneys of male rats during aging. Biogerontology 2011; 12:537–550.

Lepperdinger G. Inflammation and mesenchymal stem cell aging. Curr Opin Immunol 2011; 23:518–524.

Lu J, Wu DM, Zheng YL, Hu B, et al. Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and I kappa B kinase beta/nuclear factor-kappa B-mediated inflammatory pathways in mice. Brain Behav Immun 2011; 25:1658–1667.

Muller-Delp JM, Gurovich AN, Christou DD, Leeuwenburgh C. Redox Balance in the Aging Microcirculation: New Friends, New Foes, and New Clinical Directions. Microcirculation 2012; 19:19–28.

Njemini R, Smitz J, Demanet C, Sosso M, et al. Circulating heat shock protein 70 (Hsp70) in elderly members of a rural population from Cameroon: Association with infection and nutrition. Arch Gerontol Geriatr 2011; 53:359–363.

▪. Olivieri F, Lazzarini R, Recchioni R, et al. MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling. Age (Dordr) 2012; [Epub ahead of print] PubMed PMID:22692818. [19]

Perlstein TS, Pande R, Berliner N, Vanasse GJ. Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation. Blood 2011; 117:2800–2806.

▪▪. Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011; 192:547–556. [10]

Song Y, Shen H, Schenten D, Shan PY, et al. Aging Enhances the Basal Production of IL-6 and CCL2 in Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol 2012; 32:103.

▪▪. Tieri P, Termanini A, Bellavista E, et al. Charting the NF-κB pathway interactome map. PLoS One 2012; 7:e32678. [09]

▪. Vrieze A, van Nood E, Holleman F, et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 2012; 143:913–916. [42]

Zhou RH, Vendrov AE, Tchivilev I, Niu XL, et al. Mitochondrial Oxidative Stress in Aortic Stiffening With Age The Role of Smooth Muscle Cell Function. Arterioscler Thromb Vasc Biol 2012; 32:745.

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Aging and muscle: a neuron's perspective

Review: (pp. 21–26)

Andersson DC, Betzenhauser MJ, Reiken S, Meli AC, et al. Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging. Cell Metab 2011; 14:196–207.

Basile G, Paffumi I, D'Angelo AG, Figliomeni P, et al. Healthy centenarians show high levels of circulating interleukin-22 (IL-22). Arch Gerontol Geriatr 2012; 54:459–461.

Bautmans I, Vantieghem S, Gorus E, Grazzini YR, et al. Age-related differences in pre-movement antagonist muscle co-activation and reaction-time performance. Exp Gerontol 2011; 46:637–642.

Bori Z, Zhao ZF, Koltai E, Fatouros IG, et al. The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle. Exp Gerontol 2012; 47:417–424.

Buford TW, Cooke MB, Shelmadine BD, Hudson GM, et al. Differential gene expression of FoxO1, ID1, and ID3 between young and older men and associations with muscle mass and function. Aging Clin Exp Res 2011; 23:170–174.

Chen YT, Neto OP, Marzullo ACD, Kennedy DM, et al. Age-associated impairement in endpoint accuracy of goal-directed contractions performed with two fingers is due to altered activation of the synergistic muscles. Exp Gerontol 2012; 47:519–526.

▪▪. Comley LH, Fuller HR, Wishart TM, et al. ApoE isoform-specific regulation of regeneration in the peripheral nervous system. Hum Mol Genet 2011; 20:2406–2421. [48]

Conroy MB, Kwoh CK, Krishnan E, Nevitt MC, et al. Muscle strength, mass, and quality in older men and women with knee osteoarthritis. Arthritis Care Res 2012; 64:15–21.

De Roia G, Pogliaghi S, Adami A, Papadopoulou C, et al. Effects of priming exercise on the speed of adjustment of muscle oxidative metabolism at the onset of moderate-intensity step transitions in older adults. Am J Physiol-Regul Integr Comp Physiol 2012; 302:R1158–R1166.

▪. Deschenes MR, Roby MA, Glass EK. Aging influences adaptations of the neuromuscular junction to endurance training. Neuroscience 2011. [53]

▪. Deschenes MR. Motor Unit and Neuromuscular Junction Remodeling with Aging. Curr Aging Sci, 2011. [49]

Dillon EL, Casperson SL, Durham WJ, Randolph KM, et al. Muscle protein metabolism responds similarly to exogenous amino acids in healthy younger and older adults during NO-induced hyperemia. Am J Physiol-Regul Integr Comp Physiol 2011; 301:R1408–R1417.

Faure C, Raynaud-Simon A, Ferry A, Dauge V, et al. Leucine and citrulline modulate muscle function in malnourished aged rats. Amino Acids 2012; 42:1425–1433.


Fort AT. State of the Art in Anti-Aging Trends. Clin Geriatr Med 2011; 27:507.

Garcia LA, King KK, Ferrini MG, Norris KC, et al. 1,25(OH)(2)Vitamin D-3 Stimulates Myogenic Differentiation by Inhibiting Cell Proliferation and Modulating the Expression of Promyogenic Growth Factors and Myostatin in C2C12 Skeletal Muscle Cells. Endocrinology 2011; 152:2976–2986.

Groen BBL, Res PT, Pennings B, Hertle E, et al. Intragastric protein administration stimulates overnight muscle protein synthesis in elderly men. Am J Physiol-Endocrinol Metab 2012; 302:E52–E60.

Hao YL, Jackson JR, Wang Y, Edens N, et al. beta-Hydroxy-beta-methylbutyrate reduces myonuclear apoptosis during recovery from hind limb suspension-induced muscle fiber atrophy in aged rats. Am J Physiol-Regul Integr Comp Physiol 2011; 301:R701–R715.

Hasson CJ, Caldwell GE. Effects of Age on Mechanical Properties of Dorsiflexor and Plantarflexor Muscles. Ann Biomed Eng 2012; 40:1088–1101.

Hiroki E, Abe S, Iwanuma O, Sakiyama K, et al. A comparative study of myostatin, follistatin and decorin expression in muscle of different origin. Anat Sci Int 2011; 86:151–159.

Jackson MJ. Control of Reactive Oxygen Species Production in Contracting Skeletal Muscle. Antioxid Redox Signal 2011; 15:2477–2486.

Johannsen DL, Conley KE, Bajpeyi S, Punyanitya M, et al. Ectopic Lipid Accumulation and Reduced Glucose Tolerance in Elderly Adults Are Accompanied by Altered Skeletal Muscle Mitochondrial Activity. J Clin Endocrinol Metab 2012; 97:242–250.

King GW, Stylianou AP, Kluding PM, Jernigan SD, et al. Effects of Age and Localized Muscle Fatigue on Ankle Plantar Flexor Torque Development. J Geriatr Phys Ther 2012; 35:8–14.

Koster A, Ding JZ, Stenholm S, Caserotti P, et al. Does the Amount of Fat Mass Predict Age-Related Loss of Lean Mass, Muscle Strength, and Muscle Quality in Older Adults? J Gerontol Ser A-Biol Sci Med Sci 2011; 66:888–895.

Larkin LM, Davis CS, Sims-Robinson C, Kostrominova TY, et al. Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation. Am J Physiol-Regul Integr Comp Physiol 2011; 301:R1400–R1407.

Larsen RG, Callahan DM, Foulis SA, Kent-Braun JA. Age-related changes in oxidative capacity differ between locomotory muscles and are associated with physical activity behavior. Appl Physiol Nutr Metab 2012; 37:88–99.

▪▪. Li Y, Lee Y, Thompson WJ. Changes in aging mouse neuromuscular junctions are explained by degeneration and regeneration of muscle fiber segments at the synapse. J Neurosci 2011; 31:14910–14919. [51]

Liu XH, Yao S, Qiao RF, Levine AC, et al. Nandrolone reduces activation of Notch signaling in denervated muscle associated with increased Numb expression. Biochem Biophys Res Commun 2011; 414:165–169.

▪▪. MacDonald SW, Karlsson S, Rieckmann A, et al. Aging-related increases in behavioral variability: relations to losses of dopamine D1 receptors. J Neurosci 2012; 32:8186–8191. [19]

▪▪. Manini TM, Clark BC. Dynapenia and aging: an update. J Gerontol 2011. [01]

McKiernan SH, Colman RJ, Aiken E, Evans TD, et al. Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys. Exp Gerontol 2012; 47:229–236.

Miller CJ, Gounder SS, Kannan S, Goutam K, et al. Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle. Biochim Biophys Acta-Mol Basis Dis 2012; 1822:1038–1050.

Njemini R, Smitz J, Demanet C, Sosso M, et al. Circulating heat shock protein 70 (Hsp70) in elderly members of a rural population from Cameroon: Association with infection and nutrition. Arch Gerontol Geriatr 2011; 53:359–363.

Ogawa M, Yasuda T, Abe T. Component characteristics of thigh muscle volume in young and older healthy men. Clin Physiol Funct Imaging 2012; 32:89–93.

Ogura Y, Naito H, Kakigi R, Ichinoseki-Sekine N, et al. Effects of ageing and endurance exercise training on alpha-actinin isoforms in rat plantaris muscle. Acta Physiol 2011; 202:683–690.

▪. Pannese E. Morphological changes in nerve cells during normal aging. Brain Struct Funct 2011; 216:85–89. [15]

Peixoto JG, Dias JMD, Dias RC, da Fonseca ST, et al. Relationships between measures of muscular performance, proprioceptive acuity, and aging in elderly women with knee osteoarthritis. Arch Gerontol Geriatr 2011; 53:E253–E257.

Pennings B, Groen B, de Lange A, Gijsen AP, et al. Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men. Am J Physiol-Endocrinol Metab 2012; 302:E992–E999.

Phillips BE, Hill DS, Atherton PJ. Regulation of muscle protein synthesis in humans. Curr Opin Clin Nutr Metab Care 2012; 15:58–63.

Quadrilatero J, Alway SE, Dupont-Versteegden EE. Skeletal muscle apoptotic response to physical activity: potential mechanisms for protection. Appl Physiol Nutr Metab 2011; 36:608–617.

Raj IS, Bird SR, Shield AJ. Reliability of ultrasonographic measurement of the architecture of the vastus lateralis and gastrocnemius medialis muscles in older adults. Clin Physiol Funct Imaging 2012; 32:65–70.

Reid KF, Doros G, Clark DJ, Patten C, et al. Muscle power failure in mobility-limited older adults: preserved single fiber function despite lower whole muscle size, quality and rate of neuromuscular activation. Eur J Appl Physiol 2012; 112:2289–2301.

Ribom EL, Mellstrom D, Ljunggren O, Karlsson MK. Population-based reference values of handgrip strength and functional tests of muscle strength and balance in men aged 70-80 years. Arch Gerontol Geriatr 2011; 53:E114–E117.

Rivas DA, Morris EP, Fielding RA. Lipogenic regulators are elevated with age and chronic overload in rat skeletal muscle. Acta Physiol 2011; 202:691–701.

Rowan SL, Purves-Smith FM, Solbak NM, Hepple RT. Accumulation of severely atrophic myofibers marks the acceleration of sarcopenia in slow and fast twitch muscles. Exp Gerontol 2011; 46:660–669.

Samuel D, Rowe P, Hood V, Nicol A. The relationships between muscle strength, biomechanical functional moments and health-related quality of life in non-elite older adults. Age Ageing 2012; 41:224–230.

Sanchis-Gomar F, Gomez-Cabrera MC, Vina J. The loss of muscle mass and sarcopenia: Non hormonal intervention. Exp Gerontol 2011; 46:967–969.

Seene T, Kaasik P, Riso EM. Review on aging, unloading and reloading: Changes in skeletal muscle quantity and quality. Arch Gerontol Geriatr 2012; 54:374–380.

Shimada H, Sturnieks D, Endo Y, Kimura Y, et al. Relationship between whole body oxygen consumption and skeletal muscle glucose metabolism during walking in older adults: FDG PET study. Aging Clin Exp Res 2011; 23:175–182.

▪▪. Smith AE, Ridding MC, Higgins RD, et al. Cutaneous afferent input does not modulate motor intracortical inhibition in ageing men. Eur J Neurosci 2011; 34:1461–1469. [24]

Sung JY, Woo CH, Kang YJ, Lee KY, et al. AMPK induces vascular smooth muscle cell senescence via LKB1 dependent pathway. Biochem Biophys Res Commun 2011; 413:143–148.

Tardif N, Salles J, Landrier JF, Mothe-Satney I, et al. Oleate-enriched diet improves insulin sensitivity and restores muscle protein synthesis in old rats. Clin Nutr 2011; 30:799–806.

Timmerman KL, Dhanani S, Glynn EL, Fry CS, et al. A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults. Am J Clin Nutr 2012; 95:1403–1412.

Vidt ME, Daly M, Miller ME, Davis CC, et al. Characterizing upper limb muscle volume and strength in older adults: A comparison with young adults. J Biomech 2012; 45:334–341.

Warren DT, Shanahan CM. Defective DNA-damage repair induced by nuclear lamina dysfunction is a key mediator of smooth muscle cell aging. Biochem Soc Trans 2011; 39:1780–1785.

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Pathophysiology of the anorexia of aging

Review: (pp. 27–32)

Anderson RM, Weindruch R. The caloric restriction paradigm: Implications for healthy human aging. Am J Hum Biol 2012; 24:101–106.

Bahat G, Tufan F, Saka B, Akin S, et al. Which body mass index (BMI) is better in the elderly for functional status? Arch Gerontol Geriatr 2011; 54:78–81.

▪. Capuron L, Schoecksnadel S, Feart C, et al. Chronic low-grade inflammation in elderly persons is associated with altered tryptophan and tyrosine metabolism: role in neuropsychiatric symptoms. Biol Psychiatry 2011; 70:175–182. [38]

▪. Donini LM, Dominguez LJ, Barbagallo M, et al. Senile anorexia in different geriatric settings in Italy. J Nutr Health Aging 2011; 15:775–781. [03]

▪. Morley JE. Anorexia of aging: a true geriatric syndrome. J Nutr Health Aging 2012; 16:422–425. [24]

Morley JE. Anorexia of aging: A true geriatric syndrome. J Nutr Health Aging 2012; 16:422–425.

▪. Moss C, Dhillo WS, Frost G, Hickson M. Gastrointestinal hormones: the regulation of appetite and the anorexia of ageing. J Hum Nutr Diet 2012; 25:3–15. [35]

Moss C, Dhillo WS, Frost G, Hickson M. Gastrointestinal hormones: the regulation of appetite and the anorexia of ageing. J Hum Nutr Diet 2012; 25:3–15.

▪. Ramic E, Pranjic N, Batic-Mujanovic O, et al. The effect of loneliness on malnutrition in elderly population. Med Arh 2011; 65:92–95. [45]

▪. Rolland Y, Perrin A, Gardette V, et al. Screening older people at risk of malnutrition or malnourished using the Simplified Nutritional Appetite Questionnaire (SNAQ): a comparison with the Mini-Nutritional Assessment (MNA) tool. J Am Med Dir Assoc 2012; 13:31–34. [54]

Rosler A, Lehmann F, Krause T, Wirth R, et al. Nutritional and hydration status in elderly subjects: Clinical rating versus bioimpedance analysis. Arch Gerontol Geriatr 2010; 50:E81–E85.

Wham CA, Teh ROY, Robinson M, Kerse NM. What is associated with nutrition risk in very old age? J Nutr Health Aging 2011; 15:247–251.

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Physiology of the ageing gut

Review: (pp. 33–38)

Asuzu DT, Hayashi Y, Izbeki F, Popko LN, et al. Generalized neuromuscular hypoplasia, reduced smooth muscle myosin and altered gut motility in the klotho model of premature aging. Neurogastroenterol Motil 2011; 23:E309–E323.

Backhed F. Programming of Host Metabolism by the Gut Microbiota. Ann Nutr Metab 2011; 58:44–52.

Becker R, Nieczaj R, Egge K, Moll A, et al. Functional Dysphagia Therapy and PEG Treatment in a Clinical Geriatric Setting. Dysphagia 2011; 26:108–116.

▪▪. Gomez-Pinilla PJ, Gibbons SJ, Sarr MG, et al. Changes in interstitial cells of cajal with age in the human stomach and colon. Neurogastroenterol Motil 2011; 23:36–44. [08]

Jones RM, Mercante JW, Neish AS. Reactive Oxygen Production Induced by the Gut Microbiota: Pharmacotherapeutic Implications. Curr Med Chem 2012; 19:1519–1529.

Lacquaniti A, Donato V, Chirico V, Buemi A, et al. Obestatin: An Interesting but Controversial Gut Hormone. Ann Nutr Metab 2011; 59:193–199.

Sirakov M, Plateroti M. The thyroid hormones and their nuclear receptors in the gut: From developmental biology to cancer. Biochim Biophys Acta-Mol Basis Dis 2011; 1812:938–946.

Takeshita T, Yasui M, Tomioka M, Nakano Y, et al. Enteral Tube Feeding Alters the Oral Indigenous Microbiota in Elderly Adults. Appl Environ Microbiol 2011; 77:6739–6745.

▪. Tanaka Y, Kato T, Nishida H, et al. Is there a delayed gastric emptying of patients with early-stage, untreated Parkinson's disease? An analysis using the 13C-acetate breath test. J Neurol 2011; 258:421–426. [45]

Watson RP, Lilley E, Panesar M, Bhalay G, et al. Increased prokineticin 2 expression in gut inflammation: role in visceral pain and intestinal ion transport. Neurogastroenterol Motil 2012; 24:65.

Wyka J, Biernat J, Mikolajczak J, Piotrowska E. Assessment of dietary intake and nutritional status (MNA) in Polish free-living elderly people from rural environments. Arch Gerontol Geriatr 2011; 54:44–49.

Zaharoni H, Rimon E, Vardi H, Friger M, et al. Probiotics improve bowel movements in hospitalized elderly patients - The proage study. J Nutr Health Aging 2011; 15:215–220.

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Nutrition and skin ulcers

Review: (pp. 39–49)

▪. Baldwin C, Weekes CE. Dietary advice with or without oral nutritional supplements for disease-related malnutrition in adults. Cochrane Database Syst Rev 2011; CD002008. [23]

▪▪. Blass SC, Goost H, Tolba RH, et al. Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: a PRCT. Clin Nutr 2012; 31:469–475. [31]

Cox J. Predictors of pressure ulcers in adult critical care patients. Am J Crit Care 2011; 20:364–374.

Demirovic D, Rattan SIS. Curcumin induces stress response and hormetically modulates wound healing ability of human skin fibroblasts undergoing ageing in vitro. Biogerontology 2011; 12:437–444.

Gantwerker EA, Hom DB. Skin: Histology and Physiology of Wound Healing. Clin Plast Surg 2012; 39:85.

Ho CH, Powell HL, Collins JF, Bauman WA, et al. Poor Nutrition Is a Relative Contraindication to Negative Pressure Wound Therapy for Pressure Ulcers: Preliminary Observations in Patients with Spinal Cord Injury. Adv Skin Wound Care 2010; 23:508–516.

▪. Leigh B, Desneves K, Rafferty J, et al. The effect of different doses of an arginine-containing supplement on the healing of pressure ulcers. J Wound Care 2012; 21:150–156. [25]

▪. Ohura T, Nakajo T, Okada S, et al. Evaluation of effects of nutrition intervention on healing of pressure ulcers and nutritional states (randomized controlled trial). Wound Repair Regen 2011; 19:330–336. [29]

Peralta CA, Katz R, De Boer I, Ix J, et al. Racial and Ethnic Differences in Kidney Function Decline among Persons without Chronic Kidney Disease. J Am Soc Nephrol 2011; 22:1327–1334.

▪. Pham B, Stern A, Chen W, et al. Preventing pressure ulcers in long-term care: a cost-effectiveness analysis. Arch Intern Med 2011; 171:1839–1847. [26]

Plettig J, Johnen CM, Brautigam K, Zeilinger K, et al. Active Wound Dressing With Artificial Capillaries for Temporary Wound Irrigation and Skin Cell Supply. Artif Organs 2012; 36:446–449.

Posthauer ME, Dorner B, Collins N. Nutrition: A Critical Component of Wound Healing. Adv Skin Wound Care 2011; 23:560–572.

▪▪. Teno JM, Gozalo P, Mitchell SL, et al. Feeding tubes and the prevention or healing of pressure ulcers. Arch Intern Med 2012; 172:697–701. [28]

▪. Tsutsumi R, Tsutsumi YM, Horikawa YT, et al. Decline in anthropometric evaluation predicts a poor prognosis in geriatric patients. Asia Pac J Clin Nutr 2012; 21:44–51. [07]

▪. Williams JZ, Barbul A. Nutrition and wound healing. Crit Care Nurs Clin North Am 2012; 24:179–200. [02]

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Polypharmacy and malnutrition

Review: (pp. 50–55)

Chakkalakal JV, Kuang SH, Buffelli M, Lichtman JW, et al. Mouse transgenic lines that selectively label type I, type IIa, and types IIX plus B skeletal muscle fibers. Genesis 2012; 50:50–58.

Chang CB, Chen JH, Wen CJ, Kuo HK, et al. Potentially inappropriate medications in geriatric outpatients with polypharmacy: application of six sets of published explicit criteria. Br J Clin Pharmacol 2011; 72:482–489.

Clyne B, Bradley MC, Hughes C, Fahey T, et al. Electronic Prescribing and Other Forms of Technology to Reduce Inappropriate Medication Use and Polypharmacy in Older People: A Review of Current Evidence. Clin Geriatr Med 2012; 28:301.

Faure C, Raynaud-Simon A, Ferry A, Dauge V, et al. Leucine and citrulline modulate muscle function in malnourished aged rats. Amino Acids 2012; 42:1425–1433.

▪▪. Franssen FME, Spruit MA, Wouters EFM. Determinants of polypharmacy and compliance with GOLD guidelines in patients with chronic obstructive pulmonary disease. Int J COPD 2011; 6:493–501. [10]

Gnjidic D, Le Couteur DG, Kouladjian L, Hilmer SN. Deprescribing Trials: Methods to Reduce Polypharmacy and the Impact on Prescribing and Clinical Outcomes. Clin Geriatr Med 2012; 28:237.

Hebert-Schuster M, Cottart CH, Laguillier-Morizot C, Raynaud-Simon A, et al. Catalase rs769214 SNP in elderly malnutrition and during renutrition: Is glucagon to blame? Free Radic Biol Med 2011; 51:1583–1588.

▪▪. Heuberger RA, Caudell K. Polypharmacy and nutritional status in older adults. A cross-sectional study. Drugs Aging 2011; 28:315–323. [04]

Hovstadius B, Petersson G. Factors Leading to Excessive Polypharmacy. Clin Geriatr Med 2012; 28:159.

Jeejeebhoy KN. Malnutrition, fatigue, frailty, vulnerability, sarcopenia and cachexia: overlap of clinical features. Curr Opin Clin Nutr Metab Care 2012; 15:213–219.

▪▪. Jyrkkä J, Mursu J, Enlund H, et al. Polypharmacy and nutritional status in elderly people. Curr Opin Clin Nutr Metab Care 2012; 15:1–6. [02]

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Docosahexaenoic acid (DHA) and cognitive function

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Longevity: is there a limit?

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Nutrition and bone health: influence of age

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Socio - economic influence on nutrition quality and quantity and body mass index in the elderly

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Ageing and optical health

Aquilani R, Zuccarelli GC, Dioguardi FS, Baiardi P, et al. Effects of oral amino acid supplementation on long-term-care-acquired infections in elderly patients. Arch Gerontol Geriatr 2011; 52:E123–E128.

Steinman BA, Vasunilashorn S. Biological risk of older adults with visual impairments. J Nutr Health Aging 2011; 15:296–302.

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Neurological conditions and ageing

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Hoffmann F, van den Bussche H, Wiese B, Schon G, et al. Impact of geriatric comorbidity and polypharmacy on cholinesterase inhibitors prescribing in dementia - art. no. 190. BMC Psychiatry 2011; 11:6.

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Kim DH, Park SJ, Kim JM, Jeon SJ, et al. Cognitive dysfunctions induced by a cholinergic blockade and A beta(25-35) peptide are attenuated by salvianolic acid B. Neuropharmacology 2011; 61:1432–1440.

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Norman K, Stobaus N, Gonzalez MC, Schulzke JD, et al. Hand grip strength: Outcome predictor and marker of nutritional status. Clin Nutr 2011; 30:135–142.

Opie LH. Inhibition of the Cerebral Renin-Angiotensin System to Limit Cognitive Decline in Elderly Hypertensive Persons. Cardiovasc Drugs Ther 2011; 25:277–279.

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Schiepers OJG, van Boxtel MPJ, de Groot RHM, Jolles J, et al. DNA methylation and cognitive functioning in healthy older adults. Br J Nutr 2012; 107:744–748.

Serviddio G, Romano AD, Cassano T, Bellanti F, et al. Principles and Therapeutic Relevance for Targeting Mitochondria in Aging and Neurodegenerative Diseases. Curr Pharm Design 2011; 17:2036–2055.

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Wisnik P, Chmura J, Ziemba AW, Mikulski T, et al. The effect of branched chain amino acids on psychomotor performance during treadmill exercise of changing intensity simulating a soccer game. Appl Physiol Nutr Metab 2011; 36:856–862.

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Physical acturity and ageing

Arias P, Espinosa N, Robles-Garcia V, Cao R, et al. Antagonist muscle co-activation during straight walking and its relation to kinematics: Insight from young, elderly and Parkinson's disease.. Brain Res1455: 21.

Hemmeryckx B, Van Hove CE, Fransen P, Emmerechts J, et al. Progression of the Prothrombotic State in Aging Bmal1-Deficient Mice. Arterioscler Thromb Vasc Biol 2011; 31:2552.

Holviala J, Kraemer WJ, Sillanpaa E, Karppinen H, et al. Effects of strength, endurance and combined training on muscle strength, walking speed and dynamic balance in aging men. Eur J Appl Physiol 2012; 112:1335–1347.

Ikezoe T, Mori N, Nakamura M, Ichihashi N. Effects of age and inactivity due to prolonged bed rest on atrophy of trunk muscles. Eur J Appl Physiol 2012; 112:43–48.

Konopka AR, Trappe TA, Jemiolo B, Trappe SW, et al. Myosin Heavy Chain Plasticity in Aging Skeletal Muscle With Aerobic Exercise Training. J Gerontol Ser A-Biol Sci Med Sci 2011; 66:835–841.

Lawler JM, Hindle A. Living in a Box or Call of the Wild? Revisiting Lifetime Inactivity and Sarcopenia. Antioxid Redox Signal 2011; 15:2529–2541.

Nagalingam NA, Lynch SV. Role of the microbiota in inflammatory bowel diseases. Inflamm Bowel Dis 2012; 18:968–980.

Pasini E, Lahaye SL, Flati V, Assanelli D, et al. Effects of treadmill exercise and training frequency on anabolic signaling pathways in the skeletal muscle of aged rats. Exp Gerontol 2012; 47:23–28.

Pereira A, Izquierdo M, Silva AJ, Costa AM, et al. Effects of high-speed power training on functional capacity and muscle performance in older women. Exp Gerontol 2012; 47:250–255.

Radak Z, Bori Z, Koltai E, Fatouros IG, et al. Age-dependent changes in 8-oxoguanine-DNA glycosylase activity are modulated by adaptive responses to physical exercise in human skeletal muscle. Free Radic Biol Med 2011; 51:417–423.

Raso V, Natale VM, Duarte AJD, Greve JMD, et al. Immunological parameters in elderly women: Correlations with aerobic power, muscle strength and mood state. Brain Behav Immun 2012; 26:597–606.

Tsang WWN, Hui-Chan CWY, Fu SN. Effects of Tai Chi on pre-landing muscle response latency during stepping down while performing a concurrent mental task in older adults. Eur J Appl Physiol 2012; 112:2663–2669.

Volkers KM, de Kieviet JF, Wittingen HP, Scherder EJA. Lower limb muscle strength (LLMS): Why sedentary life should never start? A review. Arch Gerontol Geriatr 2012; 54:399–414.

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Xu JZ, Hwang JCY, Lees HA, Wohlgemuth SE, et al. Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy. Exp Gerontol 2012; 47:100–108.

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Influence on nutrition on cardiovascular function in the elderly

Boulberdaa M, Urayama K, Nebigil CG. Prokineticin receptor 1 (PKR1) signalling in cardiovascular and kidney functions. Cardiovasc Res 2011; 92:191–198.

Burgaz A, Byberg L, Rautiainen S, Orsini N, et al. Confirmed hypertension and plasma 25(OH)D concentrations amongst elderly men. J Intern Med 2011; 269:211–218.

Cadore EL, Izquierdo M, Conceicao M, Radaelli R, et al. Echo intensity is associated with skeletal muscle power and cardiovascular performance in elderly men. Exp Gerontol 2012; 47:473–478.

Cieslik KA, Trial J, Entman ML. Defective Myofibroblast Formation from Mesenchymal Stem Cells in the Aging Murine Heart Rescue by Activation of the AMPK Pathway. Am J Pathol 2011; 179:1792–1806.

Kaats GR, Preuss HG, Croft HA, Keith SC, et al. A Comparative Effectiveness Study of Bone Density Changes in Women Over 40 Following Three Bone Health Plans Containing Variations of the Same Novel Plant-sourced Calcium. Int J Med Sci 2011; 8:180–191.

Kim HJ, Ham SA, Kim MY, Hwang JS, et al. PPAR delta Coordinates Angiotensin II-induced Senescence in Vascular Smooth Muscle Cells through PTEN-mediated Inhibition of Superoxide Generation. J Biol Chem 2011; 286:44585–44593.

Lind PM, Lind L. Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderly. Atherosclerosis 2011; 218:207–213.

Padrao AI, Ferreira R, Vitorino R, Alves RMP, et al. Effect of lifestyle on age-related mitochondrial protein oxidation in mice cardiac muscle. Eur J Appl Physiol 2012; 112: 1467–1474.

Qian DH, Wu XJ, Jiang H, Gao P, et al. Aging reduces susceptibility of vascular smooth muscle cells to H2O2-induced apoptosis through the down-regulation of Jagged1 expression in endothelial cells. Int J Mol Med 2011; 28:207–213.

Rossoni LV, Oliveira RAF, Caffaro RR, Miana M, et al. Cardiac benefits of exercise training in aging spontaneously hypertensive rats. J Hypertens 2011; 29:2349–2358.

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Measurement, models, methods and treatments employed in the study of ageing

Bowman GL, Silbert LC, Howieson D, Dodge HH, et al. Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. Neurology 2012; 78:241–249.

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Manson JE, Bassuk SS, Lee IM, Cook NR, et al. The VITamin D and OmegA-3 TriaL (VITAL): Rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials 2012; 33:159–171.

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Ageing and cancer

Bauer JM. Nutrition in older persons. Basis for functionality and quality of life. Internist 2011; 52:946–954.

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Age related changes in lung function

Battaglia S, Spatafora M, Paglino G, Pedone C, et al. Ageing and COPD affect different domains of nutritional status: the ECCE study. Eur Resp J 2011; 37:1340–1345.

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Renal function in the elderly

Boulberdaa M, Urayama K, Nebigil CG. Prokineticin receptor 1 (PKR1) signalling in cardiovascular and kidney functions. Cardiovasc Res 2011; 92:191–198.

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Akin FW, Murnane OD, Tampas JW, Clinard CG. The Effect of Age on the Vestibular Evoked Myogenic Potential and Sternocleidomastoid Muscle Tonic Electromyogram Level. Ear Hear 2011; 32:617–622.

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Protein, amino acid metabolism and therapy

The role of amino acid transporters in nutrition

Review: (pp. 57–65)

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Skeletal muscle protein metabolism in human heart failure

Review: (pp. 66–71)

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Wang XF, Zhang JY, Li L, Zhao XY. Beneficial effects of metformin on primary cardiomyocytes via activation of adenosine monophosphate-activated protein kinase. Chin Med J 2011; 124:1876–1884.

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D-Serine: physiology and pathology

Review: (pp. 72–75)

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L-arginine, tetrahydrobiopterin, nitric oxide and diabetes

Review: (pp. 76–82)

Advani A, Huang QL, Thai K, Advani SL, et al. Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism. Am J Pathol 2011; 178:2205–2214.

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Muscle protein anabolism in type 2 diabetes

Review: (pp. 83–88)

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Methionine metabolic pathway in alcoholic liver injury

Review: (pp. 89–95)

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Detection of amino acid deprivation in the central nervous system

Review: (pp. 96–101)

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The nutritional burden of methylation reactions

Review: (pp. 102–108)

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