SPECIAL COMMENTARYAlcoholism and nutrition: a review of vitamin supplementation and treatmentLewis, Michael J. Author Information Department of Psychology, Hunter College, City University of New York (CUNY), New York, New York, USA Correspondence to Michael J. Lewis, PhD, Department of Psychology, Hunter College, City University of New York (CUNY), 695 Park Avenue, New York, NY 10065, USA. Tel: +1 215 815 2020; e-mail: [email protected] Current Opinion in Clinical Nutrition and Metabolic Care: March 2020 - Volume 23 - Issue 2 - p 138-144 doi: 10.1097/MCO.0000000000000622 Buy Metrics Abstract Purpose of review This is a review of the research on the effectiveness of vitamin supplementation for alcoholism and alcohol-related illnesses. The focus is on research, both clinical and basic on alcohol treatment and nutritional effectiveness of these vital nutrients. Recent findings Most of the research involves basic experiments exploring the impact of vitamin depletion or deficits on physiological systems, especially liver and brain, in rodents. These often include behavioral measures that use cognitive, learning/memory and motivation experiments that model clinical studies. These provide support for hypotheses concerning the impact of such deficiencies in clinical populations. Clinical studies are rare and involve evaluation of the outcome of supplementation usually in the context of a treatment program. Specific vitamins, dosages and treatment programs vary. Deficiencies in retinoids (vitamin A), thiamine (B1) and niacin (B3) are the most frequently investigated. However, there is a greater need for further research on other vitamins, and for more uniform supplementation and treatment procedures. Summary The literature is primarily basic research on specific vitamins. There are very significant findings with individual vitamin supplementation and combinations that show promise of our understanding of the role of vitamins in the disease of alcoholism and its treatment. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.