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Chronic inflammatory liver diseases and coffee intake

Contaldo, Franco; Santarpia, Lidia; Pasanisi, Fabrizio

Current Opinion in Clinical Nutrition & Metabolic Care: September 2019 - Volume 22 - Issue 5 - p 389–392
doi: 10.1097/MCO.0000000000000586
NUTRITION AND THE GASTROINTESTINAL TRACT: Edited by M. Isabel T.D. Correia and André Van Gossum

Purpose of review To review the healthy protective effects of coffee against several metabolic diseases and some types of cancer. In this short review, the possible preventive and/or therapeutic actions of coffee on liver function is focused.

Recent findings The protective mechanisms of coffee are various and because of several components with anti-inflammatory and antioxidant properties in addition to caffeine.

As a matter of the fact, polyphenols in decaffeinated coffee have a similar effect on liver fibrosis and on serum levels of liver enzymes as those in caffeinated coffee.

Furthermore, diterpenes may exert a detoxifying action and antioxidant activity, with benefits on liver fibrosis, cirrhosis and cancer.

Summary A regular coffee consumption may have preventive healthy effects, especially if consumed without added sugars. Certainly, coffee consumption should not be prohibited in individuals with chronic inflammatory liver diseases, including hepatocellular carcinoma.

Internal Medicine and Clinical Nutrition Unit, Interuniversity Center for Obesity and Eating disorders (CISRO), Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy

Correspondence to Lidia Santarpia, MD, PhD, Department of Clinical Medicine and Surgery, Federico II University, Via Pansini, 5, 80131 Naples, Italy. Tel: +39 81 746 2333; fax: +39 81 746 2333; e-mail:

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