NUTRITION AND PHYSIOLOGICAL FUNCTION: Edited by Labros S. Sidossis and Annemie M.W. ScholsFighting obesity by targeting factors regulating beige adipocytesMcQueen, Allison E.a; Koliwad, Suneil K.b; Wang, Jen-ChywanaAuthor Information aMetabolic Biology Graduate Program and Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley bThe Diabetes Center and Department of Medicine, University of California San Francisco, San Francisco, California, USA Correspondence to Jen-Chywan Wang, PhD, Metabolic Biology Graduate Program and Department of Nutritional Sciences and Toxicology, University of California Berkeley, 315 Morgan Hall, Berkeley, CA 94720-3104, USA. Tel: +1 510 643 1039; e-mail: firstname.lastname@example.org Current Opinion in Clinical Nutrition and Metabolic Care: November 2018 - Volume 21 - Issue 6 - p 437-443 doi: 10.1097/MCO.0000000000000509 Buy Metrics Abstract Purpose of review The current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity. Recent findings We outline recent studies revealing unrecognized mechanisms controlling beige adipocyte physiology, and summarize in particular those that underlie beige thermogenesis independently of classical uncoupling. We also update strategies aimed at fostering beige adipogenesis and white-to beige adipocyte conversion. Finally, we summarize newly identified endogenous secreted factors that promote the thermogenic activation of beige adipocytes and discuss their therapeutic potential. Summary The identification of novel endogenous factors that promote beiging and regulate beige adipocyte-specific physiological pathways opens up new avenues for therapeutic engineering targeting obesity and related metabolic disorders. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.