CARBOHYDRATES: Edited by Luc Tappy and Bettina MittendorferMetformin old friend, new ways of action–implication of the gut microbiome?Rodriguez, Julie; Hiel, Sophie; Delzenne, Nathalie M.Author Information Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium Correspondence to Prof. Nathalie M. Delzenne, Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, av. E. Mounier 73 bte B1.73.11, B-1200 Brussels, Belgium. Tel: +32 764 73 69; e-mail: [email protected] Current Opinion in Clinical Nutrition and Metabolic Care: July 2018 - Volume 21 - Issue 4 - p 294-301 doi: 10.1097/MCO.0000000000000468 Buy Metrics Abstract Purpose of review Gut dysbiosis was recently associated with the occurrence of type 2 diabetes (T2D). In addition to this finding, an increasing number of studies performed upon the last 5 years have also shown that metformin treatment leads to changes in gut bacterial composition in diabetic patients. This review focuses on the articles describing the effects of metformin on gut homeostasis (including the gut microbiota) and proposes potential mechanisms involved in those effects. Recent findings Several human and animal studies emphasized that metformin alters the gut microbiota composition by enhancing the growth of some bacteria, such as Akkermansia muciniphila, Escherichia spp. or Lactobacillus and by decreasing the levels of some other ones like Intestinibacter. In-vitro studies also demonstrated a direct action of metformin on the growth of A. muciniphila and Bifidobacterium adolescentis. Moreover, in the intestines, metformin does not only improve the glucose uptake, but it also promotes the short-chain fatty acid (SCFA) production, protects the intestinal barrier and regulates the secretion of gut peptides Summary It is now clear that gut microbiota participates to the glucose-lowering effects of metformin in the context of diabetes. Further work is now needed to determine the exact mechanisms of action of the drug and to understand by which processes metformin is able to enhance the growth of some bacteria exhibiting beneficial effects for the host. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.