CARBOHYDRATES: Edited by Luc Tappy and Bettina MittendorferDietary carbohydrates and fatty liver disease de novo lipogenesisChiu, Sallya,b; Mulligan, Kathleena,c,d; Schwarz, Jean-Marca,c,d Author Information aCollege of Osteopathic Medicine, Touro University California, Vallejo bChildren's Hospital Oakland Research Institute, Oakland cDepartment of Medicine, University of California, San Francisco dDivision of Endocrinology, Zuckerberg San Francisco General Hospital, San Francisco, California, USA Correspondence to Jean-Marc Schwarz, PhD, College of Osteopathic Medicine, Touro University California, 1310 Club Drive, Vallejo, CA 94592, USA. Tel: +1 707 638 5456; e-mail: [email protected] Current Opinion in Clinical Nutrition and Metabolic Care: July 2018 - Volume 21 - Issue 4 - p 277-282 doi: 10.1097/MCO.0000000000000469 Buy Metrics Abstract Purpose of review To review recent evidence for the role of dietary carbohydrate in de novo lipogenesis (DNL) and nonalcoholic fatty liver disease (NAFLD). Recent findings A large body of evidence suggests that increased hepatic DNL is a significant pathway contributing to the development of NAFLD. Dietary carbohydrates, in particular, fructose, have been shown to stimulate DNL and increase liver fat, although it is debated whether this is due to excess energy or fructose per se. Recent dietary intervention studies conducted in energy balance show that high-fructose diets increase DNL and liver fat, whereas fructose restriction decreases DNL and liver fat. Summary The association of high-carbohydrate and high-sugar diets with NAFLD may in part be explained by the effect of sugar on increasing hepatic DNL. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.