CARBOHYDRATES: Edited by Luc Tappy and Bettina MittendorferFructose use in clinical nutrition metabolic effects and potential consequencesMoulin, Sandraa; Seematter, Géraldb; Seyssel, Kevinc Author Information aDepartment of Critical Care Medicine, Hôpital cantonal de Fribourg, Fribourg bDepartment of Anaesthesia, Hôpital Riviera-Chablais, Montreux cDepartment of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland Correspondence to Kevin Seyssel, Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 7, 1005 Lausanne, Switzerland. Tel: +41 0 21 692 55 68; fax: +41 0 21 692 55 95; e-mail: [email protected] Current Opinion in Clinical Nutrition and Metabolic Care: July 2017 - Volume 20 - Issue 4 - p 272-278 doi: 10.1097/MCO.0000000000000376 Buy Metrics Abstract Purpose of review The current article presents recent findings on the metabolic effects of fructose. Recent findings Fructose has always been considered as a simple ‘caloric’ hexose only metabolized by splanchnic tissues. Nevertheless, there is growing evidence that fructose acts as a second messenger and induces effects throughout the human body. Summary Recent discoveries made possible with the evolution of technology have highlighted that fructose induces pleiotropic effects on different tissues. The fact that all these tissues express the specific fructose carrier GLUT5 let us reconsider that fructose is not only a caloric hexose, but could also be a potential actor of some behaviors and metabolic pathways. The physiological relevance of fructose as a metabolic driver is pertinent regarding recent scientific literature. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.