PROTEIN, AMINO ACID METABOLISM AND THERAPY: Edited by Alessandro Laviano and Rajavel ElangoGlutamine and the regulation of intestinal permeability from bench to bedsideAchamrah, Najate; Déchelotte, Pierre; Coëffier, Moïse Author Information aNormandie Univ bINSERM UMR 1073 ‘Nutrition, Inflammation and Dysfunction of Gut-brain Axis’, University of Rouen cNutrition Department, Rouen University Hospital, Rouen, France Correspondence to Dr Moïse Coëffier, INSERM Unit 1073, Institute for Research and Innovation in Biomedicine, University of Rouen, 22 Bd Gambetta, 76183 Rouen Cedex, France. Tel: +33 2 35 14 82 40; fax: +33 2 35 14 82 26; e-mail: [email protected] Current Opinion in Clinical Nutrition and Metabolic Care: January 2017 - Volume 20 - Issue 1 - p 86-91 doi: 10.1097/MCO.0000000000000339 Buy Metrics Abstract Purpose of review Glutamine is the most abundant amino acid in plasma and plays a key role in maintaining the integrity of intestinal barrier. Recent findings Experimental studies showed that glutamine is able to modulate intestinal permeability and tight junction protein expression in several conditions. Recent articles underlined its putative beneficial role in gastrointestinal disorders such as irritable bowel syndrome. Summary Glutamine is a major nutrient to maintain intestinal barrier function in animals and humans. Depletion of glutamine results in villus atrophy, decreased expression of tight junction proteins and increased intestinal permeability. Moreover, glutamine supplementation can improve gut barrier function in several experimental conditions of injury and in some clinical situations. Furthermore, preventive effects of glutamine in experimental models of intestinal injuries have been recently reported. Despite promising data in experimental models, further studies are needed to evaluate glutamine supplementation in clinical practice. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.