MICRONUTRIENTS: Edited by Edited by Henry C. Lukaski and Véronique CoxamRisks and benefits of phytoestrogens where are we now?Bennetau-Pelissero, Catherine Author Information aUniversity Bordeaux, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862 bINSERM, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215 Bordeaux cBordeaux Sciences Agro, Gradignan, France Correspondence to Catherine Bennetau-Pelissero, Neurocentre Magendie, U1215 Inserm, Physiopathology of Declarative Memory Team, 146 rue Léo Saignat, 33 077 Bordeaux, France. Tel: +33 (0) 557 573 667; fax: +33 (0) 557 573 669; e-mail: [email protected] Current Opinion in Clinical Nutrition and Metabolic Care 19(6):p 477-483, November 2016. | DOI: 10.1097/MCO.0000000000000326 Buy Metrics Abstract Purpose of review The estrogenic effects of genistein, as reconfirmed by the American National Toxicology Program (USA-NTP), have led to several new clinical studies being undertaken. Here, we highlight the most relevant recent data, reporting either beneficial or adverse effects. Recent findings Phytoestrogens are natural molecules from edible plants exhibiting estrogenic activities. Post-USA-NTP studies investigated both human and animal reproductive and other physiological issues. These studies showed that estrogens can be either deleterious for reproduction and estrogen-dependent diseases, or beneficial for those with steroid deficiencies, that is more than 50. The specific outcome depends on exposure level and on the estrogenic status of the patients exposed. Recently, it was reported that, with the industrialization of soybean process, phytoestrogen exposure dramatically increased in both humans and cattle, whereas traditional Asian soy-food-processing empirically removed isoflavones. Phytoestrogen exposure has also become more widespread with the progressive internationalization of soybean use in human and cattle food. Summary Phytoestrogens should be considered as modern endocrine disruptors and studied as such. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.