Purpose of review
This article provides an overview of the most recent human trials that have examined the impact of intermittent fasting
on glucose homeostasis
Our literature search retrieved one human trial of alternate day fasting
, and three trials of Ramadan fasting
published in the past 12 months. Current evidence suggests that 8 weeks of alternate day fasting
that produces mild weight loss (4% from baseline) has no effect on glucose homeostasis
. As for Ramadan fasting
, decreases in fasting glucose, insulin, and insulin resistance
have been noted after 4 weeks in healthy normal weight individuals with mild weight loss (1–2% from baseline). However, Ramadan fasting
may have little impact on glucoregulatory parameters in women with polycystic ovarian syndrome who failed to observe weight loss.
Whether intermittent fasting
is an effective means of regulating glucose homeostasis
remains unclear because of the scarcity of studies in this area. Large-scale, longer-term randomized controlled trials will be required before the use of fasting can be recommended for the prevention and treatment of metabolic diseases.