LIPID METABOLISM AND THERAPY: Edited by Philip C. Calder and Richard J. DeckelbaumThe diverse nature of saturated fats and the case of medium-chain triglycerides how one recommendation may not fit allBhavsar, Nilam; St-Onge, Marie-Pierre Author Information Department of Medicine, Institute of Human Nutrition, Columbia University, New York, USA Correspondence to Marie-Pierre St-Onge, PhD, FAHA, 1150 St. Nicholas Avenue, room 121H, New York, NY 10032, USA. Tel: +1 212 851 5578; fax: +1 212 851 5579; e-mail: [email protected] Current Opinion in Clinical Nutrition and Metabolic Care: March 2016 - Volume 19 - Issue 2 - p 81-87 doi: 10.1097/MCO.0000000000000249 Buy Metrics Abstract Purpose of review The adverse cardiovascular health effects of saturated fats have been debated recently since the publication of studies reporting no increase in cardiovascular risk with saturated fat intakes. We purport that this may be because of the varied nature of saturated fats, which range in length from 2 to over 20 carbon atoms, and review evidence surrounding the cardiovascular health effects of medium-chain triglycerides (MCT). Recent findings MCTs are saturated fats of shorter chain length than other, more readily consumed saturated fats. Studies have reported that consumption of MCT may lead to improvements in body composition without adversely affecting cardio-metabolic risk factors. There may also be synergistic actions between MCT and n-3 polyunsaturated fats that may lead to improvements in cardiovascular health. Summary It is clinically relevant to distinguish between sources of saturated fats for cardiovascular health. Medium, and possibly shorter chain, saturated fats behave differently than long-chain saturated fats and should not be judged similarly when it comes to their cardio-metabolic health effects. Given their neutral, and potentially beneficial cardiovascular health effects, they should not be categorized together. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.