The role of polydextrose in body weight control and glucose regulationCanfora, Emanuel E.; Blaak, Ellen E.Current Opinion in Clinical Nutrition & Metabolic Care: July 2015 - Volume 18 - Issue 4 - p 395–400 doi: 10.1097/MCO.0000000000000184 CARBOHYDRATES: Edited by Luc Tappy and Bettina Mittendorfer Buy Abstract Author InformationAuthors Article MetricsMetrics Purpose of review The purpose of this review was to highlight recent research developments on effects of the dietary fibre polydextrose (PDX) on appetite, satiety and energy intake and glucose metabolism. For this purpose, clinically relevant human studies were reviewed and putative mechanisms and pathways were discussed. Recent findings A number of acute human intervention studies provide strong indications for an energy and glucose metabolism-regulating role of PDX. These effects might be mediated via a reduced gastro-intestinal transit reducing glycaemia and insulinemia after PDX ingestion and the potential of PDX as soluble dietary fibre to alter the intestinal microbial composition, which might lead to changes in signalling in both peripheral and central pathways involved in energy metabolism and glucose homeostasis. Summary In acute studies, PDX seems to have an inhibiting effect on energy intake and satiety and to reduce glycaemic and insulinemic response through effect on gastro-intestinal transit time and macronutrient absorption as well as through effects of the microbial products such as short-chain fatty acids on energy and substrate metabolism. In particular, well controlled human intervention studies are required to confirm these effects in the long term. Overall, supplement PDX to the daily diet may be a promising approach for the management and treatment of obesity and associated metabolic disorders. Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands Correspondence to Ellen E. Blaak, Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Universiteitssingel 50, 6229 ER, PO Box 616, 6200 MD, Maastricht, The Netherlands. Tel: +0031 43 3881503; fax: +0031 43 3670976; e-mail: email@example.com Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.