Nutrients or even diets affect the epigenome by lifelong remodeling. Nutritional imbalances are associated with noncommunicable diseases. Thus, nutriepigenomics is a promising field in the treatment of complex human diseases.
The epigenome is susceptible to changes and can be shaped by nutritional states, especially in prenatal period through transgenerational mechanisms and in early postnatal life when critical developmental processes are taking place. Although more stable, the epigenetic marks in adulthood are also dynamic and modifiable by environmental factors including diet.
The present review is focused on the most recent knowledge of epigenetically active nutrients/diets including transgenerational inheritance and prenatal predispositions related to increased risk for cancer, metabolic syndrome, and neurodegenerative diseases.
aDepartment of Nutritional Sciences, University Vienna, Vienna, Austria
bDepartment of Nutrition Science, Purdue University, West Lafaytte, Indiana, USA
cDepartment of Gynecology and Obstetrics, Clinical Institute of Medical Genetics, University Medical Centre Ljubljana, Ljubljana, Slovenia
Correspondence to Marlene Remely, Department of Nutritional Sciences, University Vienna, Althanstraße 14, 1090 Vienna, Austria. Tel: +0043 4277 54997; e-mail: email@example.com