LIPID METABOLISM AND THERAPY: Edited by Philip C. Calder and Richard J. DeckelbaumOmega-3 polyunsaturated fatty acids and chronic obstructive pulmonary diseaseWood, Lisa G.Author Information School of Biomedical Sciences and Pharmacy, Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, NSW, Australia Correspondence to Lisa G. Wood, Level 2, West Wing, HMRI Building, Kookaburra Crt, New Lambton Heights, NSW 2305, Australia. Tel: +61 2 40420147; fax: +61 2 40420046; e-mail: [email protected] Current Opinion in Clinical Nutrition and Metabolic Care: March 2015 - Volume 18 - Issue 2 - p 128-132 doi: 10.1097/MCO.0000000000000142 Buy Metrics Abstract Purpose of review The aim of the present review was to summarize recent research developments relating omega-3 polyunsaturated fatty acids (PUFAs) and chronic obstructive pulmonary disease (COPD). Recent findings COPD is a chronic inflammatory disease; hence, omega-3 PUFAs may have beneficial effects. At present, however, there are limited data available regarding the potential for omega-3 PUFAs to be used therapeutically in COPD. In 2012–2013, several observational studies have emerged, which demonstrate that circulating omega-3 PUFA levels in COPD are inversely associated with systemic inflammation and positively associated with clinical outcomes. To date, all interventions incorporating omega-3 PUFAs in COPD have used nutrient combinations, such that the specific effects of omega-3 PUFAs cannot be determined. Three clinical trials in COPD are underway, which use therapeutic doses of omega-3 PUFAs alone, with positive results beginning to emerge in 2014. Summary Observational data support the hypothesis that omega-3 PUFAs may provide a therapeutic strategy for managing COPD. Several intervention trials using omega-3 PUFAs in COPD are underway, which will provide a substantive amount of new data to inform the field and allow evidence-based advice to be generated for patients with COPD in the near future. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.