LIPID METABOLISM AND THERAPY: Edited by Philip C. Calder and Richard J. DeckelbaumEarly fatty acid exposure and later obesity riskHauner, Hans; Brunner, StefanieAuthor Information Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany Correspondence to Hans Hauner, MD, Else Kröner-Fresenius-Centre for Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Uptown Munich Campus D, Georg-Brauchle-Ring 60/62, 80992 Munich, Germany. Tel: +49 8161 71 2001; fax: +49 8161 71 2097; e-mail: [email protected] Current Opinion in Clinical Nutrition and Metabolic Care: March 2015 - Volume 18 - Issue 2 - p 113-117 doi: 10.1097/MCO.0000000000000143 Buy Metrics Abstract Purpose of review The impact of fatty acids in early nutrition on later body composition and obesity risk remains elusive. Aim of this review was to summarize and discuss recent studies on the role of early supply with long-chain polyunsaturated fatty acids (LCPUFAs) through maternal nutrition during pregnancy and lactation for later offspring obesity. Recent findings Recent human studies, either interventional or observational, investigating the role of dietary fatty acids, in particular of LCPUFAs, on body composition and later obesity risk provide inconsistent results concerning BMI as well as fat mass development in the offspring. A recent meta-analysis of randomized controlled trials found no significant effect of maternal supplementation with n-3 LCPUFA on BMI in both preschool and school-aged children. Summary There is currently no conclusive evidence that dietary intervention to modify fat intake during pregnancy and lactation is a reasonable strategy to prevent childhood obesity in humans, but more research is clearly needed to address this issue. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.