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Glycemic index: is it a predictor of metabolic and vascular disorders?

Rizkalla, Salwa W.

Current Opinion in Clinical Nutrition & Metabolic Care: July 2014 - Volume 17 - Issue 4 - p 373–378
doi: 10.1097/MCO.0000000000000070
CARBOHYDRATES: Edited by Luc Tappy and Bettina Mittendorfer

Purpose of review The role of glycemic index on metabolic and cardiovascular risk factors received considerable attention in light of the current increase in cardiometabolic disorders. We aimed to deal and identify the recently published prospective epidemiological studies as well as randomized controlled studies investigating the associations of metabolic and cardiovascular risk markers with dietary intake of carbohydrates and with measures of the induced glycemic index. The main prospective studies and meta-analysis grouping the recent prospective and clinical interventions are discussed.

Recent findings Recently, during the last few years, evidence exists that high glycemic index/glycemic load diets contribute to risk of type 2 diabetes and cardiovascular disease. Additionally, low glycemic index/glycemic load diets were found to be effective in the treatment of cardiometabolic disorders.

Summary The use of the low glycemic index notion in the dietary recommendations for children, adolescents and adults might play a role in the prevention, and or treatment, of metabolic diseases and their cardiovascular complications.

aInstitute of Cardiometabolism and Nutrition(ICAN), Assistance Publique-Hôpitaux de Paris, and Human Nutrition Research Center-Ile de France, Hôpital Pitié-Salpêtrière, Paris, F-75013, France

bINSERM, UMRS U1166 (Eq 6) Nutriomics UPMC, Sorbonne University, Pierre et Marie Curie-Paris 6, Paris 75006 France

Correspondence to Salwa Rizkalla, ICAN, Institute of Cardiometabolism and Nutrition, E3M building, 6th floor, Pitié-Salpêtrière Hospital; 83 Boulevard de l’hôpital. 75013, Paris. Tel: +33 1 42 17 79 81; e-mail:

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