Cellular senescence and the senescent secretory phenotype in age-related chronic diseasesZhu, Yi; Armstrong, Jacqueline L.; Tchkonia, Tamara; Kirkland, James L.Current Opinion in Clinical Nutrition & Metabolic Care: July 2014 - Volume 17 - Issue 4 - p 324–328 doi: 10.1097/MCO.0000000000000065 GENES AND CELL METABOLISM: Edited by Philip Newsholme and Paulo Ivo Homem de Bittencourt Jr Abstract Author Information Purpose of review Possible mechanisms in cellular senescence and the senescence-associated secretory phenotype (SASP) that drive and promote chronic inflammation in multiple age-related chronic diseases are considered. Recent findings A series of studies about the SASP indicate that senescent cells may be involved in the development of chronic inflammatory diseases associated with aging. Summary Aging is a complex biological process accompanied by a state of chronic, low-grade, ‘sterile’ inflammation, which is a major contributor to the development of many age-related chronic disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes, cancers, and others. It appears that cellular senescence plays a role in causing inflammation through the SASP. A better understanding of the contribution of senescent cells to the pathologies of chronic inflammatory disorders could have potentially profound diagnostic and therapeutic implications. Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA Correspondence to James L. Kirkland, Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street, S.W, Rochester, Minnesota 55905, USA. Tel: +1 507 266 9151; fax: +1 507 293 3853; e-mail: firstname.lastname@example.org Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.