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Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

Zhu, Yi; Armstrong, Jacqueline L.; Tchkonia, Tamara; Kirkland, James L.

Current Opinion in Clinical Nutrition & Metabolic Care: July 2014 - Volume 17 - Issue 4 - p 324–328
doi: 10.1097/MCO.0000000000000065
GENES AND CELL METABOLISM: Edited by Philip Newsholme and Paulo Ivo Homem de Bittencourt Jr

Purpose of review Possible mechanisms in cellular senescence and the senescence-associated secretory phenotype (SASP) that drive and promote chronic inflammation in multiple age-related chronic diseases are considered.

Recent findings A series of studies about the SASP indicate that senescent cells may be involved in the development of chronic inflammatory diseases associated with aging.

Summary Aging is a complex biological process accompanied by a state of chronic, low-grade, ‘sterile’ inflammation, which is a major contributor to the development of many age-related chronic disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes, cancers, and others. It appears that cellular senescence plays a role in causing inflammation through the SASP. A better understanding of the contribution of senescent cells to the pathologies of chronic inflammatory disorders could have potentially profound diagnostic and therapeutic implications.

Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA

Correspondence to James L. Kirkland, Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street, S.W, Rochester, Minnesota 55905, USA. Tel: +1 507 266 9151; fax: +1 507 293 3853; e-mail:

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