Despite current therapy, coronary artery disease (CAD) remains the major cause of morbidity and mortality worldwide. CAD is the consequence of a complex array of deranged metabolic processes including the immune system. In this context, monocytes and macrophages are indisputable players. Thus, monocyte gene expression analysis could be a powerful tool to provide new insights in the pathophysiology of CAD and improve identification of individuals at risk. We discuss current literature assessing monocyte gene expression and its association with CAD.
Monocyte surface markers CD14++ and CD16+ have been established as biomarkers for increased cardiovascular disease risk in a large number of studies. More in-depth gene expression analysis identified several interesting genes, such as ABCA1, CD36 and MSR1 with an increased expression in circulating monocytes from patients with CAD. The results for CD36 were replicated in one other study. For ABCA1 and MSR1 conflicting data are published.
Recent findings indicate that genetic differences exist in circulating monocytes of patients suffering from CAD, giving us more insights into the underlying mechanisms. However, larger studies are required to prove that monocytes’ expression signature could serve as a marker for diagnostic purposes in the future.
aDepartment of Vascular Medicine, Academic Medical Center, Amsterdam
bDepartment of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands
cCardiovascular Research Center
dCenter for Human Genomic Research, Massachusetts General Hospital, Boston, USA
Correspondence to S. Sivapalaratnam, Department of Vascular Medicine, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. E-mail: firstname.lastname@example.org