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Inflammation and diminished iron status: mechanisms and functional outcomes

Gaffney-Stomberg, Erin; McClung, James P.

Current Opinion in Clinical Nutrition & Metabolic Care: November 2012 - Volume 15 - Issue 6 - p 605–613
doi: 10.1097/MCO.0b013e328357f63b
MICRONUTRIENTS: Edited by Gil Hardy and Henry Lukaski

Purpose of review To summarize recent findings regarding the effects of inflammation on iron (Fe) metabolism and to review studies detailing the influence of poor Fe status on physical and cognitive performance.

Recent findings Hepatic expression and release of hepcidin, a negative regulator of Fe status, is increased by the actions of the inflammatory cytokine interleukin-6. Inflammation associated with chronic disease, obesity, and exercise is associated with elevated interleukin-6 and hepcidin levels, which may result in diminished Fe status.

Summary Decrements in Fe status due to insufficient dietary Fe intake and/or the inflammatory response may degrade physical and cognitive performance. Future studies should clarify whether dietary or other therapeutic interventions to mitigate inflammation attenuate hepcidin-mediated declines in Fe status.

Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA

Correspondence to Dr James P. McClung, Kansas St., Bldg 42, Natick, MA 01760, USA. Tel: +1 508 233 4979; e-mail:

© 2012 Lippincott Williams & Wilkins, Inc.